Ortho-hydroxy atorvastatin lactone-d5

Modify Date: 2024-01-08 18:03:45

Ortho-hydroxy atorvastatin lactone-d5 structure	Common Name	Ortho-hydroxy atorvastatin lactone-d5
	CAS Number	265989-50-2	Molecular Weight	561.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₂₈D₅FN₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ortho-hydroxy atorvastatin lactone-d5

Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

Name	5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-(2,3,4,5,6-pentadeuteriophenyl)-2-propan-2-ylpyrrole-3-carboxamide
Synonym	More Synonyms

Description	Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790. [3]. Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.

Molecular Formula	C₃₃H₂₈D₅FN₂O₅
Molecular Weight	561.65
Exact Mass	561.26900
PSA	104.28000
LogP	6.88310

2-Hydroxy Atorvastatin Lactone-d5

Ortho-hydroxy atorvastatin lactone-d5

Use of Ortho-hydroxy atorvastatin lactone-d5

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Ortho-hydroxy atorvastatin lactone-d5 Biological Activity

Chemical & Physical Properties

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