Maurocalcine

Modify Date: 2024-01-13 12:07:48

Maurocalcine structure	Common Name	Maurocalcine
	CAS Number	269745-22-4	Molecular Weight	3858.55
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅₆H₂₇₀N₅₆O₄₆S₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Maurocalcine

Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].

Name	Maurocalcine

Description	Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Others
References	[1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. [2]. Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406(2):309-15. [3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Others

References

[1]. De Waard S, et al. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999.

[2]. Altafaj X, et al. Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification. Biochem J. 2007 Sep 1;406(2):309-15.

[3]. Boisseau S, et al. Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor. Biochim Biophys Acta. 2006 Mar;1758(3):308-19.

Molecular Formula	C₁₅₆H₂₇₀N₅₆O₄₆S₆
Molecular Weight	3858.55

Maurocalcine

Use of Maurocalcine

Names

Maurocalcine Biological Activity

Chemical & Physical Properties