STING agonist-31 structure
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Common Name | STING agonist-31 | ||
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CAS Number | 2719001-44-0 | Molecular Weight | 873.96 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C43H51N15O6 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of STING agonist-31STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1]. |
Name | STING agonist-31 |
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Description | STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1]. |
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Related Catalog | |
In Vitro | STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING,EC50 值为 0.24 和 39.51 μM[1]。 STING agonist-31 (0-10 μM,24 h) 激活 ISG 信号和 NF-κB 信号[1]。 |
In Vivo | STING agonist-31 (化合物 40) (10 mg/kg,静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。 STING agonist-31 (1 mg/kg,静脉注射) 在大鼠中显示出 T1/2:0.697 h,AUClast 678 h•ng/mL[1]< /sup>. Animal Model: Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] Dosage: 10 mg/kg Administration: i.v., at days 1, 4, and 7 Result: Inhibited tumor Growth. |
References |
Molecular Formula | C43H51N15O6 |
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Molecular Weight | 873.96 |