STING agonist-31

Modify Date: 2024-01-18 18:04:42

STING agonist-31 Structure
STING agonist-31 structure
Common Name STING agonist-31
CAS Number 2719001-44-0 Molecular Weight 873.96
Density N/A Boiling Point N/A
Molecular Formula C43H51N15O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of STING agonist-31


STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].

 Names

Name STING agonist-31

 STING agonist-31 Biological Activity

Description STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. STING agonist-31 has antitumor efficiency[1].
Related Catalog
In Vitro STING agonist-31 (化合物 40) 激活 h-STING 和 m-STING,EC50 值为 0.24 和 39.51 μM[1]。 STING agonist-31 (0-10 μM,24 h) 激活 ISG 信号和 NF-κB 信号[1]。
In Vivo STING agonist-31 (化合物 40) (10 mg/kg,静脉注射) 抑制 4T1 和 CT26 小鼠肿瘤模型中的肿瘤生长[1]。 STING agonist-31 (1 mg/kg,静脉注射) 在大鼠中显示出 T1/2:0.697 h,AUClast 678 h•ng/mL[1]< /sup>. Animal Model: Mice models bearing orthotopic transplanted breast tumor (4T1) or subcutaneous transplanted colon tumor (CT26)[1] Dosage: 10 mg/kg Administration: i.v., at days 1, 4, and 7 Result: Inhibited tumor Growth.
References

[1]. Song Z, et al. Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists. J Med Chem. 2021 Feb 11;64(3):1649-1669.  

 Chemical & Physical Properties

Molecular Formula C43H51N15O6
Molecular Weight 873.96