Treprostinil-d9

Modify Date: 2024-04-03 08:35:00

Treprostinil-d9 Structure
Treprostinil-d9 structure
Common Name Treprostinil-d9
CAS Number 2747918-14-3 Molecular Weight 399.57
Density N/A Boiling Point N/A
Molecular Formula C23H25D9O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Treprostinil-d9


Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441)[1]. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

 Names

Name Treprostinil-d9

 Treprostinil-d9 Biological Activity

Description Treprostinil-d9 (UT-15-d9) is the deuterium-labeled Treprostinil (HY-100441)[1]. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
Related Catalog
Target

EC50: 0.6±0.1 nM (DP1), 6.2±1.2 nM (EP2)[1]

In Vitro 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

 Chemical & Physical Properties

Molecular Formula C23H25D9O5
Molecular Weight 399.57
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