DX3-213B

Modify Date: 2024-04-06 15:46:52

DX3-213B Structure
DX3-213B structure
Common Name DX3-213B
CAS Number 2749555-66-4 Molecular Weight 478.57
Density N/A Boiling Point N/A
Molecular Formula C20H28F2N2O5S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DX3-213B


DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM). DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM). DX3-213B is used for the research of the pancreatic cancer[1].

 Names

Name DX3-213B

 DX3-213B Biological Activity

Description DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC50=3.6 nM). DX3-213B impairs ATP generation (IC50=11 nM), and blocks MIA PaCa-2 cell growth (GI50=11 nM). DX3-213B is used for the research of the pancreatic cancer[1].
Related Catalog
References

[1]. Xue D, et al. Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer. J Med Chem. 2022;65(4):3404-3419.

 Chemical & Physical Properties

Molecular Formula C20H28F2N2O5S2
Molecular Weight 478.57