WAY 161503 hydrochloride
Modify Date: 2024-01-19 16:43:51
WAY 161503 hydrochloride structure
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Common Name | WAY 161503 hydrochloride | ||
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| CAS Number | 276695-22-8 | Molecular Weight | 308.59 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H12Cl3N3O | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of WAY 161503 hydrochloride(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects[1][2]. |
| Name | 8,9-dichloro-1,2,3,4,4a,6-hexahydropyrazino[1,2-a]quinoxalin-5-one,hydrochloride |
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| Synonym | More Synonyms |
| Description | (Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects[1][2]. |
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| Related Catalog | |
| Target |
5-HT2C Receptor:4 nM (Ki) 5-HT2C Receptor:12 nM (EC50) |
| In Vivo | (Rac)-WAY-161503 (3-30 mg/kg；腹腔注射；雄性 C57BL/6J 小鼠) hydrochloride 剂量依赖性地降低运动活动，这种作用被 5-HT2C/2B 拮抗剂 SER-082 所阻断[1]。 Animal Model: Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Intraperitoneal injection (i.p.) Result: Antagonized the PGE2-mediated inhibition of LPS-induced TNF-α release from rat whole blood culture, in a dose-dependent way. |
| References |
| Molecular Formula | C11H12Cl3N3O |
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| Molecular Weight | 308.59 |
| Exact Mass | 307.00500 |
| PSA | 47.86000 |
| LogP | 3.00460 |
| RIDADR | NONH for all modes of transport |
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| HS Code | 2934999090 |
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice.
Neuropsychopharmacology 34 , 1958-67, (2009) Although it is well established that hallucinogens act as 5-HT(2A) and 5-HT(2C) receptor agonists, little is known about the relative contributions of 5-HT(2A) and 5-HT(2C) receptors to the acute beha... |
| 8,9-Dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride |
| 8,9-DICHLORO-2,3,4,4A-TETRAHYDRO-1H-PYRAZINO[1,2-A]QUINOXALIN-5(6H)-ONE HYDROCHLORIDE |