terofenamate

Modify Date: 2024-01-13 20:41:30

terofenamate Structure
terofenamate structure
Common Name terofenamate
CAS Number 29098-15-5 Molecular Weight 354.22800
Density 1.297g/cm3 Boiling Point 439ºC at 760 mmHg
Molecular Formula C17H17Cl2NO3 Melting Point N/A
MSDS N/A Flash Point 219.3ºC

 Names

Name ethoxymethyl 2-(2,6-dichloro-3-methylanilino)benzoate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.297g/cm3
Boiling Point 439ºC at 760 mmHg
Molecular Formula C17H17Cl2NO3
Molecular Weight 354.22800
Flash Point 219.3ºC
Exact Mass 353.05900
PSA 47.56000
LogP 5.26920
Vapour Pressure 6.6E-08mmHg at 25°C
Index of Refraction 1.597

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB2975100
CHEMICAL NAME :
Anthranilic acid, N-(2,6-dichloro-m-tolyl)-, ethoxymethyl ester
CAS REGISTRY NUMBER :
29098-15-5
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C17-H17-Cl2-N-O3
MOLECULAR WEIGHT :
354.25
WISWESSER LINE NOTATION :
GR CG D1 BMR BVO1O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
307 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
274 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
918 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6240 mg/kg/26W-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
REFERENCE :
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 115,41,1976

 Safety Information

HS Code 2922509090

 Synthetic Route

~%

terofenamate Structure

terofenamate

CAS#:29098-15-5

Literature: Salimbeni; Manghisi; Magistretti Farmaco, Edizione Scientifica, 1975 , vol. 30, # 4 p. 276 - 286

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Terofenamato [INN-Spanish]
Etofen
Etoclofene
EINECS 249-434-4
Terofenamate
N-(2,6-Dichloro-m-tolyl)anthranilic acid ethoxymethyl ester
M-(2,6-Dichloro-m-tolyl)anthranilic acid ethoxymethyl ester
Ethoxymethyl N-(2,6-dichloro-m-tolyl)anthranilate
Terofenamatum [INN-Latin]