L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide

Modify Date: 2024-01-23 17:32:44

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure
L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide structure
Common Name L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide
CAS Number 30189-48-1 Molecular Weight 279.33500
Density 1.146g/cm3 Boiling Point 505.3ºC at 760mmHg
Molecular Formula C14H21N3O3 Melting Point 131-136ºC
MSDS N/A Flash Point 259.4ºC

 Names

Name tert-butyl N-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.146g/cm3
Boiling Point 505.3ºC at 760mmHg
Melting Point 131-136ºC
Molecular Formula C14H21N3O3
Molecular Weight 279.33500
Flash Point 259.4ºC
Exact Mass 279.15800
PSA 93.45000
LogP 2.59440
Index of Refraction 1.536

 MSDS

Name: tert-Butyl N-(1-benzyl-2-hydrazino-2-oxoethyl)carbamate 97% Material Safety Data Sheet
Synonym: N-(tert-Butoxycarbonyl)-L-phenylalanine acid hydrazid
CAS: 30189-48-1
Section 1 - Chemical Product MSDS Name:tert-Butyl N-(1-benzyl-2-hydrazino-2-oxoethyl)carbamate 97% Material Safety Data Sheet
Synonym:N-(tert-Butoxycarbonyl)-L-phenylalanine acid hydrazid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
30189-48-1 tert-Butyl N-(1-benzyl-2-hydrazino-2-o 97% unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 30189-48-1: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 131 - 136 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C14H21N3O3
Molecular Weight: 279

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, acids, acid chlorides.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 30189-48-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
tert-Butyl N-(1-benzyl-2-hydrazino-2-oxoethyl)carbamate - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 30189-48-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 30189-48-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 30189-48-1 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases 36/37/38
Safety Phrases 26-36/37/39
HS Code 2928000090

 Synthetic Route

~82%

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure

L-Phenylalanine...

CAS#:30189-48-1

Literature: Borg, Susanna; Estenne-Bouhtou, Genevieve; Luthman, Kristina; Csoeregh, Ingeborg; Hesselink, Willy; Hacksell, Uli Journal of Organic Chemistry, 1995 , vol. 60, # 10 p. 3112 - 3120

~70%

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure

L-Phenylalanine...

CAS#:30189-48-1

Literature: Matveeva; Kolesnikova; Zefirov Russian Chemical Bulletin, 2011 , vol. 60, # 2 p. 248 - 253

~85%

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure

L-Phenylalanine...

CAS#:30189-48-1

Literature: Da Costa, Cristiane F.; Pinheiro, Alessandra C.; De Almeida, Mauro V.; Lourenco, Maria C.S.; De Souza, Marcus V.N. Chemical Biology and Drug Design, 2012 , vol. 79, # 2 p. 216 - 222

~%

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure

L-Phenylalanine...

CAS#:30189-48-1

Literature: Liu, Zhuqing; Myers, Michael C.; Shah, Parag P.; Beavers, Mary Pat; Benedetti, Phillip A.; Diamond, Scott L.; Smith, Amos B.; Huryn, Donna M. Combinatorial Chemistry and High Throughput Screening, 2010 , vol. 13, # 4 p. 337 - 351

~%

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure

L-Phenylalanine...

CAS#:30189-48-1

Literature: Da Costa, Cristiane F.; Pinheiro, Alessandra C.; De Almeida, Mauro V.; Lourenco, Maria C.S.; De Souza, Marcus V.N. Chemical Biology and Drug Design, 2012 , vol. 79, # 2 p. 216 - 222

~%

L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide Structure

L-Phenylalanine...

CAS#:30189-48-1

Literature: Da Costa, Cristiane F.; Pinheiro, Alessandra C.; De Almeida, Mauro V.; Lourenco, Maria C.S.; De Souza, Marcus V.N. Chemical Biology and Drug Design, 2012 , vol. 79, # 2 p. 216 - 222

 Customs

HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

Boc-Phe-NHNH2
(S)-tert-butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
tert-butyl N-(1-benzyl-2-hydrazino-2-oxoethyl)carbamate
Boc-L-Phe hydrazide
N-(Boc)-L-phenylalanine hydrazide
Boc-L-PheNHNH2
<(S)-2-<(tert-Butyloxycarbonyl)amino>-3-phenylpropanoyl>hydrazine
tert-butyl (1S)-1-benzyl-2-hydrazino-2-oxoethylcarbamate
N-(tert-Butoxycarbonyl)-L-phenylalanine acid hydrazide