14-3-3 inhibitor BV2
Modify Date: 2024-04-02 18:59:34
14-3-3 inhibitor BV2 structure
|
Common Name | 14-3-3 inhibitor BV2 | ||
|---|---|---|---|---|
| CAS Number | 302602-92-2 | Molecular Weight | 395.366 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H17N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 14-3-3 inhibitor BV2A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation; induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively; promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels, induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. |
| Name | 2-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbamoyl]terephthalic acid |
|---|---|
| Synonym | More Synonyms |
| Description | A novel nonpeptidic inhibitor of 14-3-3 protein-protein interaction that promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation; induces significant dose-dependent reduction of reproductive integrity of Ba/F3 cells expressing the wt and T315I-mutated Bcr-Abl with LD50 of 1.04 and 1.47 uM, respectively; promoted c-Abl release from 14-3-3σ, abolishes c-Abl expression in the cytoplasm, but has no influence on 14-3-3σ levels, induces apoptotic cell death in chronic myeloid leukemia sensitive or resistant to imatinib. |
|---|---|
| References | References 1. Mancini M, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):596-604. 2. Mohammad DK, et al. Mol Cell Biol. 2013 Aug;33(16):3214-26. 3. Gómez-Suárez M, et al. Cell Death Differ. 2016 Jun;23(6):1060-72. 4. Valensin D, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):894-898. View Related Products by Target 14-3-3 Protein |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H17N3O6 |
| Molecular Weight | 395.366 |
| Exact Mass | 395.111725 |
| LogP | 0.08 |
| Index of Refraction | 1.714 |
| 1,4-Benzenedicarboxylic acid, 2-[[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino]carbonyl]- |
| 2-[(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbamoyl]terephthalic acid |