Didemethylclomipramine

Modify Date: 2024-01-02 18:30:26

Didemethylclomipramine Structure
Didemethylclomipramine structure
 Common Name Didemethylclomipramine
CAS Number 303-48-0 Molecular Weight 337.28700
Density 1.129g/cm3 Boiling Point 439.5ºC at 760mmHg
Molecular Formula C18H22Cl2N2 Melting Point N/A
MSDS Chinese USA Flash Point 219.6ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Didemethylclomipramine


Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.

 Names

Name n-desmethylclomipramine hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.129g/cm3
Boiling Point 439.5ºC at 760mmHg
Molecular Formula C18H22Cl2N2
Molecular Weight 337.28700
Flash Point 219.6ºC
Exact Mass 336.11600
PSA 15.27000
LogP 5.44410
Index of Refraction 1.583

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases 20/21/22
Safety Phrases 36
RIDADR NONH for all modes of transport
HS Code 2933990090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles27

More Articles
Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.

Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000)

Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami...

Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.

J. Affect. Disord. 29(4) , 267-79, (1993)

We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D...

Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.

Am. J. Vet. Res. 61(1) , 80-5, (2000)

To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages....

 Synonyms

Demethylchlorimipramine
[3-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-methyl-amine
N-Desmethylclomipramine HCl
Norclomipramine
n-desmethylclomipramine
Chlordesipramine
desmethylclomipramine
N-Demethylclomipramine
N-Desmethylchlomipramine
Desmethylchlomipramine
Demethylchlomipramine
Desmethylchlorimipramine
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Didemethylclomipramine
62724-32-7
Chemsrc provides Didemethylclomipramine(CAS#:303-48-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Didemethylclomipramine are included as well.>> amp version: Didemethylclomipramine

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