L(+)-Ornithine hydrochloride

Modify Date: 2024-01-02 14:51:59

L(+)-Ornithine hydrochloride structure	Common Name	L(+)-Ornithine hydrochloride
	CAS Number	3184-13-2	Molecular Weight	168.622
	Density	1.57	Boiling Point	308.7ºC at 760 mmHg
	Molecular Formula	C₅H₁₃ClN₂O₂	Melting Point	245 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	140.5ºC

Use of L(+)-Ornithine hydrochloride

L-Ornithine Hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.

Name	L(+)-Ornithine hydrochloride
Synonym	More Synonyms

Description	L-Ornithine Hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
Related Catalog	Natural Products >> Others Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. Demura S, et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43.

Density	1.57
Boiling Point	308.7ºC at 760 mmHg
Melting Point	245 °C (dec.)(lit.)
Molecular Formula	C₅H₁₃ClN₂O₂
Molecular Weight	168.622
Flash Point	140.5ºC
Exact Mass	168.066559
PSA	89.34000
LogP	1.33980
Index of Refraction	24 ° (C=4, 6mol/L HCl)

L(+)-Ornithine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM2985000

CHEMICAL NAME :: Ornithine, monohydrochloride, L-

CAS REGISTRY NUMBER :: 3184-13-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H12-N2-O2.Cl-H

MOLECULAR WEIGHT :: 168.65

WISWESSER LINE NOTATION :: Z3YZVQ &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4776 No. of Facilities: 162 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2955 (estimated) No. of Female Employees: 2312 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RM2985000
HS Code	2922499990

1,1-dimethyleth...

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L(+)-Ornithine ...

CAS#:3184-13-2

Literature: European Journal of Organic Chemistry, , # 21 p. 4391 - 4396

tert-butyl (2S)...

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L(+)-Ornithine ...

CAS#:3184-13-2

Literature: European Journal of Organic Chemistry, , # 21 p. 4391 - 4396

Ornithin-t-buty...

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L(+)-Ornithine ...

CAS#:3184-13-2

Literature: Siebum, Arjan H. G.; Tsang, Robert K. F.; Van Der Steen, Rob; Raap, Jan; Lugtenburg, Johan European Journal of Organic Chemistry, 2004 , # 21 p. 4391 - 4396

L-Arginine hydr...

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L(+)-Ornithine ...

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Urea

CAS#:57-13-6

Literature: Journal of Chemical Thermodynamics, , vol. 25, # 2 p. 293 - 305

Precursor 4
CAS#:271601-28-6 1,1-dimethyleth... CAS#:824956-17-4 tert-butyl (2S)... CAS#:26302-89-6 Ornithin-t-buty... CAS#:1119-34-2 L-Arginine hydr...
DownStream 10
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CAS#:147071-84-9 N'-Fmoc-L-ornithine CAS#:40216-82-8 H-Orn-OMe.2HCl CAS#:42538-31-8 (S)-3-amino-2-p... CAS#:92235-39-7 (S)-3-(Boc-amin...
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3184-13-2 preparation

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.

Am. J. Respir. Cell. Mol. Biol. 48(6) , 694-702, (2013)

Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes. The product of arginase activit...

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Int. J. Syst. Evol. Microbiol. 64(Pt 7) , 2267-73, (2014)

Two novel strains, THG-C26(T) and THG-C31(T), were characterized using a polyphasic approach to determine their taxonomic positions. These two isolates were aerobic, Gram-stain-positive, non-motile, n...

Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.

Dev. Med. Child Neurol. 56(10) , 1021-4, (2014)

Hyperargininaemia is a disorder of the last step of the urea cycle. It is an autosomal recessive disease caused by deficiency of liver arginase-1 and usually presents later in childhood with progressi...

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L(+)-Ornithine hydrochloride

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