SKF-34288 hydrochloride

Modify Date: 2024-01-13 22:19:15

SKF-34288 hydrochloride Structure
SKF-34288 hydrochloride structure
Common Name SKF-34288 hydrochloride
CAS Number 320386-54-7 Molecular Weight 191.63500
Density N/A Boiling Point N/A
Molecular Formula C6H6ClNO2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SKF-34288 hydrochloride


SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor.SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway[1]. SKF-34288 hydrochloride inhibits Asn metabolism and results in an increase in amino acids and amides[2].

 Names

Name 3-sulfanylpyridine-2-carboxylic acid,hydrochloride
Synonym More Synonyms

 SKF-34288 hydrochloride Biological Activity

Description SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor.SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway[1]. SKF-34288 hydrochloride inhibits Asn metabolism and results in an increase in amino acids and amides[2].
Related Catalog
Target

IC50: PEPCK[1]

References

[1]. https://www.ncbi.nlm.nih.gov/pubmed/26322521

[2]. Bailey KJ, et al. Nitrogen recycling from the xylem in rice leaves: dependence upon metabolism and associated changes in xylem hydraulics. J Exp Bot. 2016 Apr;67(9):2901-11.

 Chemical & Physical Properties

Molecular Formula C6H6ClNO2S
Molecular Weight 191.63500
Exact Mass 190.98100
PSA 88.99000
LogP 1.87050

 Synonyms

3-Mercapto-2-pyridinecarboxylic Acid Hydrochloride
3-Mercaptopicolinic Acid Hydrochloride