oxfenicine

Modify Date: 2024-01-02 19:58:12

oxfenicine Structure
oxfenicine structure
Common Name oxfenicine
CAS Number 32462-30-9 Molecular Weight 167.162
Density 1.4±0.1 g/cm3 Boiling Point 365.8±32.0 °C at 760 mmHg
Molecular Formula C8H9NO3 Melting Point 240ºC (dec.)
MSDS Chinese USA Flash Point 175.0±25.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of oxfenicine


Oxfenicine, also known as UK-25842, is a carnitine palmitoyltransferase I (CPT-1) inhibitor involved in fatty acid metabolism in the heart. In animal studies oxfenicine acts as a cardioprotective agent during ischemia. Oxfenicine produces changes in myocardial substrate utilisation and is attributed to the protection of ischemic stressed myocardium by shifting the cardiac metabolism with reduction of FFA (Free Fatty Acid) utilisation. This may be favourable in circumstances with limited oxygen supply.

 Names

Name (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 365.8±32.0 °C at 760 mmHg
Melting Point 240ºC (dec.)
Molecular Formula C8H9NO3
Molecular Weight 167.162
Flash Point 175.0±25.1 °C
Exact Mass 167.058243
PSA 69.56000
LogP 0.20
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.633

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2922509090

 Synthetic Route

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles25

More Articles
Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.

Am. J. Physiol. Heart Circ. Physiol. 294(6) , H2576-86, (2008)

The role of proton (H+) production from glucose metabolism in the recovery of myocardial function during postischemic reperfusion and its alteration by insulin and other metabolic modulators were exam...

The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus.

Microbiology 152(Pt 10) , 2969-83, (2006)

The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and sequenced from Streptomyces fungicidicus ATCC 21013. The 84 kb gene cluster contains 25 ORFs and is locat...

Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux.

Biochim. Biophys. Acta 1821(4) , 627-36, (2012)

Cardiac hypertrophy is characterised by an imbalance between lipid uptake and fatty acid β-oxidation leading to an accumulation of lipids, particularly triacylglycerol (TAG). It is unclear whether upt...

 Synonyms

L-(+)-2-(4-Hydroxyphenyl)glycine
4-Hydroxy-L-(+)-2-phenylglycine
oxfenicine
4-Hydroxy-L-phenylglycine
L-P-HYDROXYPHENYGLYCINE
(aS)-a-Amino-4-hydroxybenzeneacetic Acid
Benzeneacetic acid, α-amino-4-hydroxy-, (αS)-
H-Phg(4-OH)-OH
EINECS 251-061-7
(2S)-Amino(4-hydroxyphenyl)acetic acid
(S)-a-Amino-4-hydroxybenzeneacetic Acid
(S)-2-Amino-2-(4-hydroxyphenyl)acetic acid
MFCD00065932
(2S)-amino(4-hydroxyphenyl)ethanoic acid
L-4-Hydroxyphenylglycine
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