ICA-027243
Modify Date: 2024-01-19 00:13:51
ICA-027243 structure
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Common Name | ICA-027243 | ||
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| CAS Number | 325457-89-4 | Molecular Weight | 268.64700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H7ClF2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ICA-027243ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2]. |
| Name | N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide |
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| Synonym | More Synonyms |
| Description | ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 of 0.38 μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and anticonvulsant effects[1][2]. |
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| Related Catalog | |
| Target |
EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[2] |
| In Vitro | In SH-SY5Y human neuroblastoma cells, ICA-27243 produces membrane potential hyperpolarization that could be prevented by coadministration with the M-current inhibitors XE-991 and Linopirdine. ICA-27243 enhances both 86Rb+ efflux (EC50 = 0.2 μM) and whole-cell currents in Chinese hamster ovary cells stably expressing heteromultimeric KCNQ2/Q3 channels (EC50 = 0.4 μM). Activation of KCNQ2/Q3 channels is associated with a hyperpolarizing shift of the voltage dependence of channel activation (V1/2 shift of -19 mV at 10 μM)[1]. |
| In Vivo | ICA-27243 (1-100 mg/kg; oral administration; male CD-1 mice) has anticonvulsant activity (ED50 of 8.4 mg/kg) in the mouse maximal electroshock epilepsy model[1]. Animal Model: Male CD-1 mice with electroshock assay[1] Dosage: 1-100 mg/kg Administration: Oral administration Result: Produced a dose-dependent increase in the latency to hind limb extension, exhibiting an ED50 value of 8.4 mg/kg. |
| References |
| Molecular Formula | C12H7ClF2N2O |
|---|---|
| Molecular Weight | 268.64700 |
| Exact Mass | 268.02100 |
| PSA | 45.48000 |
| LogP | 3.64950 |
| Benzamide,N-(6-chloro-3-pyridinyl)-3,4-difluoro |
| ZTZ233 |
| UNII-VU7278D853 |