CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GZ2150000
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CHEMICAL NAME :
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1,2-Cyclopropanedicarboximide, N-(3,5-dichlorophenyl)-1,2-dimethyl-
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CAS REGISTRY NUMBER :
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32809-16-8
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BEILSTEIN REFERENCE NO. :
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1539058
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LAST UPDATED :
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199710
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DATA ITEMS CITED :
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18
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MOLECULAR FORMULA :
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C13-H11-Cl2-N-O2
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MOLECULAR WEIGHT :
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284.15
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WISWESSER LINE NOTATION :
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T35 DVNVTJ A1 C1 ER CG EG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7 gm/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>2500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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730 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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7800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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7800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1560 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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10 gm/kg
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TOXIC EFFECTS :
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Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - somnolence (general depressed activity) Behavioral - ataxia
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Bird - quail
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DOSE/DURATION :
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>6637 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Bird - duck
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DOSE/DURATION :
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>4 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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>10 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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25480 mg/kg/26W-I
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TOXIC EFFECTS :
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Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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36400 mg/kg/26W-I
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TOXIC EFFECTS :
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Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Bird - quail
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DOSE/DURATION :
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1190 mg/kg/7D-C
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TOXIC EFFECTS :
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Gastrointestinal - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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360 mg/kg
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SEX/DURATION :
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male 14 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - other effects on male Endocrine - changes in luteinizing hormone Endocrine - androgenic
MUTATION DATA
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TYPE OF TEST :
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Morphological transformation
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TEST SYSTEM :
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Rodent - mouse Fibroblast
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DOSE/DURATION :
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50 mg/L
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,81,1993
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