5-methylaminomethyl-2-thiouridine

Modify Date: 2024-01-30 12:08:59

5-methylaminomethyl-2-thiouridine Structure
5-methylaminomethyl-2-thiouridine structure
Common Name 5-methylaminomethyl-2-thiouridine
CAS Number 32860-54-1 Molecular Weight 303.33500
Density N/A Boiling Point N/A
Molecular Formula C11H17N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-methylaminomethyl-2-thiouridine


Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].

 Names

Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(methylaminomethyl)-2-sulfanylidenepyrimidin-4-one
Synonym More Synonyms

 5-methylaminomethyl-2-thiouridine Biological Activity

Description Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].
Related Catalog
In Vitro An E. coli strain deficient in mnm5s2U is more vulnerable to oxidative RNA damage compared to its wildtype strain suggesting an auxiliary function for the mnm5s2U modification[1].
References

[1]. Mariana Estevez, et al. Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides. Front Mol Biosci. 2021 Jul 1;8:697149.

 Chemical & Physical Properties

Molecular Formula C11H17N3O5S
Molecular Weight 303.33500
Exact Mass 303.08900
PSA 152.09000

 Synonyms

5-methylaminomethyl-2-thiouridine
Uridine,5-[(methylamino)methyl]-2-thio
2-Thio-5-(N-methylaminomethyl)uridine
5-N-Methylaminomethyl-2-thiouridine
2-Thio-5-methylaminomethyluridine