Aprinocarsen sodium
Modify Date: 2024-01-12 00:37:31
Aprinocarsen sodium structure
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Common Name | Aprinocarsen sodium | ||
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| CAS Number | 331257-53-5 | Molecular Weight | 6852.85 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C196H230N68Na19O105P19S19 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Aprinocarsen sodiumAprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers[1]. |
| Name | Aprinocarsen sodium |
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| Description | Aprinocarsen (ISIS 3521) sodium, a specific antisense oligonucleotide inhibitor of protein kinase C-alpha (PKC-α). Aprinocarsen sodium is a 20-mer oligonucleotide, it regulates cell differentiation and proliferation. Aprinocarsen sodium inhibits the growth of human tumor cell lines in nude mice. Aprinocarsen sodium shows the value as a chemotherapeutic compound of human cancers[1]. |
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| Related Catalog | |
| In Vitro | Aprinocarsen sodium dose-dependently and oligonucleotide sequence specifically inhibits PKC-alpha in human bladder carcinoma (T-24) cells[1]. Aprinocarsen sodium shows an IC50 value of 50-100 nM for PKC-α mRNA reduction, but it shows no effect on the expression of other members of the PKC family of genes (PKC-eta and zeta)[1]. |
| In Vivo | Aprinocarsen sodium (100 mg/kg; i.v.; at repeat doses for 14 days) shows well tolerated character with no apparently acute toxicity[1]. Aprinocarsen sodium (i.v.) dose-dependently inhibits the growth of T-24 bladder, human lung carcinoma (A549) and Colo 205 colon carcinoma human tumor cell lines in nude mice with ID50 values of 0.06-0.6 mg/kg daily[1]. |
| References |
| Molecular Formula | C196H230N68Na19O105P19S19 |
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| Molecular Weight | 6852.85 |