Anabase

Modify Date: 2024-01-10 18:53:12

Anabase structure	Common Name	Anabase
	CAS Number	3471-05-4	Molecular Weight	160.22
	Density	1.09g/cm3	Boiling Point	263.9ºC at 760mmHg
	Molecular Formula	C₁₀H₁₂N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	113.4ºC

Use of Anabase

Anabaseine, an alkaloid, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular receptors and α7 AChRs[1].

Name	3-(2,3,4,5-tetrahydropyridin-6-yl)pyridine
Synonym	More Synonyms

Description	Anabaseine, an alkaloid, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular receptors and α7 AChRs[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	anabaseine (3.6 μmol/kg; subcutaneous injection) has a peak effect values of 50%, 85%, 62% for acetylcholine, dopamine and norepinephrine, respectively [1][2] . anabaseine act as neuromuscular agonists on the frog rectus abdominis muscle whit a EC50 of 0.25-0.74 μM[1].
References	[1]. [1] Kem W, et al. The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties. Mar Drugs. 2006;4(3):255-273. [2]. [2] Summers KL et al. Nicotinic agonist modulation of neurotransmitter levels in the rat frontoparietal cortex. Jpn J Pharmacol. 1997 Jun;74(2):139-46.

Density	1.09g/cm3
Boiling Point	263.9ºC at 760mmHg
Molecular Formula	C₁₀H₁₂N₂
Molecular Weight	160.22
Flash Point	113.4ºC
Exact Mass	160.10000
PSA	25.25000
LogP	1.49020
Index of Refraction	1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DW1890000

CHEMICAL NAME :: 2,3'-Bipyridine, 3,4,5,6-tetrahydro-

CAS REGISTRY NUMBER :: 3471-05-4

BEILSTEIN REFERENCE NO. :: 0125981

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H12-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 32,684,1976

HS Code	2933399090

1-pyridin-3-ylc...

CAS#:81417-95-0

~74%

Anabase

CAS#:3471-05-4

Literature: Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M. Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940

lithium,3H-pyri...

CAS#:60573-68-4

Anabase

CAS#:3471-05-4

Literature: Alberici, Gilles F.; Andrieux, Jean; Adam, Gerard; Plat, Michel M. Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1937 - 1940

Ethyl nicotinate

CAS#:614-18-6

N/A

CAS#:161564-43-8

Anabase

CAS#:3471-05-4

Literature: Shevchenko, Nikolay E.; Vlasov, Katja; Nenajdenko, Valentine G.; Roeschenthaler, Gerd-Volker Tetrahedron, 2011 , vol. 67, # 1 p. 69 - 74

3-Bromopyridine

CAS#:626-55-1

Anabase

CAS#:3471-05-4

Literature: Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

2-Piperidone

CAS#:675-20-7

Anabase

CAS#:3471-05-4

Literature: Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

1-Boc-2-piperidone

CAS#:85908-96-9

Anabase

CAS#:3471-05-4

Literature: Giovannini, Arianna; Savoia, Diego; Umani-Ronchi, Achille Journal of Organic Chemistry, 1989 , vol. 54, # 1 p. 228 - 234

Ethyl nicotinate

CAS#:614-18-6

1-benzoylpiperi...

CAS#:4252-56-6

Sodium ethoxide

CAS#:141-52-6

benzene

CAS#:71-43-2

Detail

Literature: Spaeth; Mamoli Chemische Berichte, 1936 , vol. 69, p. 757,760 Full Text Show Details Duffield et al. Journal of the American Chemical Society, 1965 , vol. 87, p. 2926,2027 Full Text Show Details Kamimura; Yamamoto Agricultural and Biological Chemistry, 1963 , vol. 27, p. 450,453

Ethyl nicotinate

CAS#:614-18-6

1-benzoylpiperi...

CAS#:4252-56-6

Anabase

CAS#:3471-05-4

Literature: Spaeth; Mamoli Chemische Berichte, 1936 , vol. 69, p. 1082,1085

Precursor 9
CAS#:81417-95-0 1-pyridin-3-ylc... CAS#:60573-68-4 lithium,3H-pyri... CAS#:614-18-6 Ethyl nicotinate CAS#:626-55-1 3-Bromopyridine
CAS#:675-20-7 2-Piperidone CAS#:85908-96-9 1-Boc-2-piperidone CAS#:4252-56-6 1-benzoylpiperi... CAS#:141-52-6 Sodium ethoxide
CAS#:71-43-2 benzene
DownStream 2
CAS#:581-50-0 2,3'-Bipyridine CAS#:13078-04-1 (±)-Anabasine

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

anabaseine dihydrochloride

2,3'-BIPYRIDINE,3,4,5,6-TETRAHYDRO

Anabaseine

3,4,5,6-tetrahydro-2,3'-bipyridine

DC Chemicals Limited
China
Product Name: Anabaseine
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

Anabase suppliers

Anabase price

Anabase

Use of Anabase

Names

Anabase Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms