Epoprostenol

Modify Date: 2024-01-09 09:37:29

Epoprostenol structure	Common Name	Epoprostenol
	CAS Number	35121-78-9	Molecular Weight	374.44700
	Density	1.221g/cm3	Boiling Point	530.2ºC at 760mmHg
	Molecular Formula	C₂₀H₃₁NaO₅	Melting Point	N/A
	MSDS	N/A	Flash Point	182.1ºC

Use of Epoprostenol

Epoprostenol (Prostaglandin I2), the synthetic form of the natural prostaglandin derivative Prostacyclin (Prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH. Epoprostenol is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[1].

Name	prostaglandin I2
Synonym	More Synonyms

Description	Epoprostenol (Prostaglandin I2), the synthetic form of the natural prostaglandin derivative Prostacyclin (Prostaglandin I2), is registered worldwide for the treatment of Pulmonary arterial hypertension (PAH. Epoprostenol is used in pulmonary hypertension and transplantation as a potent inhibitor of platelet aggregation[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	Human Endogenous Metabolite
References	[1]. Provencher S, et al.Quality of life, safety and efficacy profile of thermostable flolan in pulmonary arterialhypertension. PLoS One. 2015 Mar 20;10(3):e0120657.

Density	1.221g/cm3
Boiling Point	530.2ºC at 760mmHg
Molecular Formula	C₂₀H₃₁NaO₅
Molecular Weight	374.44700
Flash Point	182.1ºC
Exact Mass	374.20700
PSA	89.82000
LogP	2.07380
Index of Refraction	1.611

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8008500

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, (5Z,9-alpha,11-alpha,13E,15S)-

CAS REGISTRY NUMBER :: 35121-78-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H32-O5

MOLECULAR WEIGHT :: 352.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 15-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: GOBIDS Gynecologic and Obstetric Investigation. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.9- 1978- Volume(issue)/page/year: 33,193,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 800 ng/kg

SEX/DURATION :: female 1-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Maternal Effects - other effects

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 94,279,1992

Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	S22;S26;S36

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PROSTAGLANDINS ...

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PGX

Epoprostenol

MFCD00135629

Prostaglandin l2

prostacyclin

Vasocyclin

PGl2

ProstaglandinI

PGX(prostaglandin)

Cyclo-Prostin

EINECS 263-273-7

Prostaglandin X

Epoprostenol

Use of Epoprostenol

Names

Epoprostenol Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Synonyms