Semapimod
Modify Date: 2024-01-01 23:09:20
Semapimod structure
|
Common Name | Semapimod | ||
|---|---|---|---|---|
| CAS Number | 352513-83-8 | Molecular Weight | 744.90 | |
| Density | 1.39 | Boiling Point | N/A | |
| Molecular Formula | C34H52N18O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SemapimodSemapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3]. |
| Name | N,N'-bis[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide |
|---|---|
| Synonym | More Synonyms |
| Description | Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CD40 IL-1β IL-6 p38 MAPK |
| References |
| Density | 1.39 |
|---|---|
| Molecular Formula | C34H52N18O2 |
| Molecular Weight | 744.90 |
| Exact Mass | 744.45200 |
| PSA | 355.24000 |
| LogP | 7.12260 |
| Index of Refraction | 1.677 |
| AXD455 |
| UNII-9SGW2H1K8P |
| Semapimod |
| CNI-1493 |