HBED dihydrochloride

Modify Date: 2024-01-06 22:16:40

HBED dihydrochloride Structure
HBED dihydrochloride structure
Common Name HBED dihydrochloride
CAS Number 35369-53-0 Molecular Weight 461.34
Density N/A Boiling Point N/A
Molecular Formula C20H26Cl2N2O6 Melting Point 130-134ºC
MSDS N/A Flash Point N/A

 Use of HBED dihydrochloride


HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy[1].

 Names

Name hbed hcl h2o
Synonym More Synonyms

 HBED dihydrochloride Biological Activity

Description HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy[1].
Related Catalog
In Vivo HBED monohydrochloride dihydrate 在不同的给药方式下,产生的活性不同。HBED 以 81、162 和 324 μMol/kg 的剂量,口服给药后不会产生显著效果。而以 162 和 324 μMol/kg 的剂量,在皮下给药后,提高了净铁排泄量[1]。
References

[1]. Bergeron RJ, et al. HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Blood. 1999 Jan 1;93(1):370-5.  

 Chemical & Physical Properties

Melting Point 130-134ºC
Molecular Formula C20H26Cl2N2O6
Molecular Weight 461.34
Exact Mass 388.16300
PSA 121.54000
LogP 1.57120

 MSDS


Section 1: Product Identification
Chemical Name:N,N'-Di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid monohydrochloride hydrate HBED
CAS Registry Number:35369-53-0
Formula:C20H24N2O6.HCl.XH2O
EINECS Number:none
Chemical Family:organic amine
Synonym:none

Section 2: Composition and Information on Ingredients
IngredientCAS NumberPercentACGIH (TWA)OSHA (PEL)
Title Compound35369-53-0100%no datano data

Section 3: Hazards Identification
Emergency Overview:No particular hazard associated with this material.
Primary Routes of Exposure:Ingestion, inhalation
Eye Contact:May cause slight to mild irritation of the eyes.
Skin Contact:May cause slight to mild irritation of the skin.
Inhalation:May be irritating to the nose, mucous membranes and respiratory tract.
Ingestion:No specific information is available on the physiological effects of ingestion.
Acute Health Affects:May be irritating to skin, eyes and respiratory tract.
Chronic Health Affects:No information available on long-term chronic effects.
NTP:No
IARC:No
OSHA:No

SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.

SECTION 5: Fire Fighting Measures
Flash Point:no data
Autoignition Temperature:none
Explosion Limits:none
Extinguishing Medium:carbon dioxide, dry powder or foam
If this material is involved in a fire, fire fighters should be equipped with a NIOSH approved, positive pressure
Special Fire Fighting Procedures:
self contained breathing apparatus and full protective clothing.
Hazardous Combustion andIf involved in a fire this material may emit toxic organic fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: No unusual fire or explosion hazards.

SECTION 6: Accidental Release Measures
Spill and Leak Procedures:Small spills can be mixed with vermiculite or sodium carbonate and swept up.

SECTION 7: Handling and Storage
Handling and Storage:Store in a tightly sealed container. Keep away from heat and direct sunlight.

SECTION 8: Exposure Controls and Personal Protection
Eye Protection:Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection:Wear protective clothing and gloves.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation:Material may form a fine dust. If possible, handle the material in an efficient fume hood.
Additional Protection:No additional protection required.

SECTION 9: Physical and Chemical Properties
Color and Form:off-white pwdr.
Molecular Weight:424.89
Melting Point:130-134°
Boiling Point:no data
Vapor Pressure:not applicable
Specific Gravity:no data
Odor:none
Solubility in Water:soluble

SECTION 10: Stability and Reactivity
Stability:air and moisture stable solid
Hazardous Polymerization:no hazardous polymerization
Conditions to Avoid:none
Incompatibility:Oxidizing agents and halogens
Decomposition Products:carbon dioxide, carbon monoxide, nitrogen oxides, hydrogen chloride, and organic fumes

SECTION 11: Toxicological Information
RTECS Data:No information available in the RTECS files.
Carcinogenic Effects:No data available
Mutagenic Effects:No data available
Tetratogenic Effects:No data available

SECTION 12: Ecological Information
Ecological Information:No information available

SECTION 13: Disposal Considerations
Disposal:Dispose of according to local, state and federal regulations.

SECTION 14: Transportation
Shipping Name (CFR):Non-hazardous
Hazard Class (CFR):NA
Additional Hazard Class (CFR):NA
Packaging Group (CFR):NA
UN ID Number (CFR):NA
Shipping Name (IATA):Non-hazardous
Hazard Class (IATA):NA
Additional Hazard Class (IATA):NA
Packaging Group (IATA):NA
UN ID Number (IATA):NA

SECTION 15: Regulatory Information
TSCA:Not listed in the TSCA inventory.
SARA (Title 313):Not reportable under SARA Title 313
Second Ingredient:none


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Risk Phrases 36/37/38
Safety Phrases 26-36/37/39

 Synonyms

hbed 2hcl 2h2o