Megestrol

Modify Date: 2024-01-05 10:31:16

Megestrol Structure
Megestrol structure
Common Name Megestrol
CAS Number 3562-63-8 Molecular Weight 342.472
Density 1.2±0.1 g/cm3 Boiling Point 500.4±50.0 °C at 760 mmHg
Molecular Formula C22H30O3 Melting Point N/A
MSDS N/A Flash Point 270.5±26.6 °C

 Use of Megestrol


Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1].

 Names

Name megestrol
Synonym More Synonyms

 Megestrol Biological Activity

Description Megestrol is a synthetic progestin and used for the treatment of anorexia, cachexia, or an unexplained significant weight loss in patients with an acquired immunodeficiency syndrome diagnosis[1].
References

[1]. Garcia JM, et al. Off-Label Megestrol in Patients with Anorexia-Cachexia Syndrome Associated with Malignancy and Its Treatments. Am J Med. 2018 Jun;131(6):623-629.e1.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 500.4±50.0 °C at 760 mmHg
Molecular Formula C22H30O3
Molecular Weight 342.472
Flash Point 270.5±26.6 °C
Exact Mass 342.219482
PSA 54.37000
LogP 3.06
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.569

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU4074500
CHEMICAL NAME :
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
CAS REGISTRY NUMBER :
3562-63-8
LAST UPDATED :
199606
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H20-O3
MOLECULAR WEIGHT :
332.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg/15D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 11(3),17,1991

 Synonyms

MFCD01939877
EINECS 222-628-6
17-Hydroxy-6-methyl-pregna-4,6-dien-3,20-dion
17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
4,6-PREGNADIEN-6-METHYL-17-OL-3,20-DIONE
Megestrol
Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-
20-dione,17-hydroxy-6-methyl-pregna-6-diene-3
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Price: ¥550/10 mM * 1 mL in DMSO

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