Bucladesine

Modify Date: 2024-01-03 16:33:55

Bucladesine Structure
Bucladesine structure
Common Name Bucladesine
CAS Number 362-74-3 Molecular Weight 469.386
Density 1.7±0.1 g/cm3 Boiling Point N/A
Molecular Formula C18H24N5O8P Melting Point 203 - 205 °C
MSDS N/A Flash Point N/A

 Use of Bucladesine


Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. Bucladesine is a phosphodiesterase inhibitor. Bucladesine is a cell permeable cAMP analog. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. cAMP is only able to elicit minimal responses in these situations. The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone.

 Names

Name Bucladesine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Melting Point 203 - 205 °C
Molecular Formula C18H24N5O8P
Molecular Weight 469.386
Exact Mass 469.136261
PSA 173.80000
LogP 1.76300
Index of Refraction 1.717

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ES5055000
CHEMICAL NAME :
Butyramide, N-(9-beta-D-ribofuranosyl-9H-furin-6-yl)-, cyclic 3',5'-(hydrogen phosphate) 2'- butyrate
CAS REGISTRY NUMBER :
362-74-3
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C18-H24-N5-O8-P
MOLECULAR WEIGHT :
469.44
WISWESSER LINE NOTATION :
T56 BO FOPOTJ DOV3 GQ GO C- DT56 BN DN FN HNJ IMV3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
50 umol/L
REFERENCE :
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 66,313,1976

 Synonyms

dibutyryl cAMP
Bt2 cyclic AMP
(4aR,6R,7R,7aR)-6-[6-(butanoylamino)-9H-purin-9-yl]-2-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butanoate
3',5'-Cyclic AMP dibutyrate
n-6,o-2'-dibutyryl adenosine cyclic 3':5'-monophosphate
Cyclic AMP dibutyrate
N-(9-b-D-Ribofuranosyl-9H-purin-6-yl)butyramide Cyclic 3',5'-(Hydrogen Phosphate) 2'-Butyrate
N6,2'-O-Dibutyryl cAMP
N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate
Butanoic acid, (4aR,6R,7R,7aR)-tetrahydro-2-hydroxy-2-oxido-6-[6-[(1-oxobutyl)amino]-9H-purin-9-yl]-4H-furo[3,2-d]-1,3,2-dioxaphosphorin-7-yl ester
N6,2'-O-dibutyryl-cAMP
Bucladesine
(4aR,6R,7R,7aR)-6-[6-(Butyrylamino)-9H-purin-9-yl]-2-hydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl butyrate
Dibutyryl cyclic 3',5'-AMP
dibutyryl cyclic AMP
CalciuM Dibutyacyladenosine
N,O-dibutyryl cyclic AMP
N-(9-beta-D-Ribofuranosyl-9H-furin-6-yl)-butyramidecyclic3',5'-(hydrogenphosphate)2'-butyrate
N-(1-Oxobutyl)adenosine Cyclic 3',5'-(Hydrogen Phosphate) 2'-Butanoate
Dibutyryl-cAMP
Dibutyryl 3',5'-Cyclic AMP
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