3'-O-dephosphono-coenzyme A

Modify Date: 2024-01-06 10:29:56

3'-O-dephosphono-coenzyme A Structure
3'-O-dephosphono-coenzyme A structure
Common Name 3'-O-dephosphono-coenzyme A
CAS Number 3633-59-8 Molecular Weight 687.55400
Density 1.85±0.1 g/cm3(Predicted) Boiling Point N/A
Molecular Formula C21H35N7O13P2S Melting Point N/A
MSDS USA Flash Point N/A

 Use of 3'-O-dephosphono-coenzyme A


Dephospho-CoA is A direct precursor of Coenzyme A (CoA). Dephospho-CoA kinase (DPCK) catalyzes the ATP-dependent phosphorylation of Dephospho-CoA, the final step in coenzyme A (CoA) biosynthesis[1][2].

 Names

Name 3'-dephospho-CoA
Synonym More Synonyms

 3'-O-dephosphono-coenzyme A Biological Activity

Description Dephospho-CoA is A direct precursor of Coenzyme A (CoA). Dephospho-CoA kinase (DPCK) catalyzes the ATP-dependent phosphorylation of Dephospho-CoA, the final step in coenzyme A (CoA) biosynthesis[1][2].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Swift RP, et al. Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption. EMBO J. 2021 Aug 16;40(16):e107247.  

[2]. Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019 Jul 23;10(4):e01146-19.  

 Chemical & Physical Properties

Density 1.85±0.1 g/cm3(Predicted)
Molecular Formula C21H35N7O13P2S
Molecular Weight 687.55400
Exact Mass 687.14900
PSA 358.45000

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles25

More Articles
Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats.

Anal. Biochem. 430(2) , 151-5, (2012)

We describe here a simultaneous high-performance liquid chromatography method for practical and rapid determination of coenzyme A (CoA), dephospho-CoA, and acetyl-CoA in tissues. These coenzymes are b...

Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases.

Biochemistry 39(43) , 13233-40, (2000)

Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage t...

Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.

J. Biol. Chem. 274(38) , 27105-11, (1999)

Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyropho...

 Synonyms

3′-Dephosphocoenzyme A
3'-DEPHOSPHOCOENZYME A