(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline

Modify Date: 2024-04-05 13:17:50

(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline Structure
(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline structure
Common Name (4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline
CAS Number 364750-81-2 Molecular Weight 229.273
Density 1.2±0.1 g/cm3 Boiling Point 343.2±35.0 °C at 760 mmHg
Molecular Formula C11H19NO4 Melting Point N/A
MSDS N/A Flash Point 161.4±25.9 °C

 Names

Name (2S,4S)-N-Boc-4-Methylpyrrolidine-2-Carboxylic Acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 343.2±35.0 °C at 760 mmHg
Molecular Formula C11H19NO4
Molecular Weight 229.273
Flash Point 161.4±25.9 °C
Exact Mass 229.131409
PSA 66.84000
LogP 1.05
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.491

 Synthetic Route

~92%

(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline Structure

(4S)-1-(tert-Bu...

CAS#:364750-81-2

Literature: Raines, Ronald T.; Shoulders, Matthew D.; Hodges, Jonathan A. Patent: US2007/275897 A1, 2007 ; Location in patent: Page/Page column 6; sheet 4 ;

~59%

(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline Structure

(4S)-1-(tert-Bu...

CAS#:364750-81-2

Literature: VERTEX PHARMACEUTICALS INCORPORATED; HENDERSON, James A.; MAXWELL, John; VAILLANCOURT, Louis; MORRIS, Mark; GREY, JR., Ronald; GIROUX, Simon; KONG, Laval Chan Chun; DAS, Sanjoy Kumar; LIU, Bingcan; POISSON, Carl; CADILHAC, Caroline; BUBENIK, Monica; REDDY, T. Jagadeeswar; FALARDEAU, Guy; YANNOPOULOS, Constantin; WANG, Jian; PEREIRA, Oswy Z.; BENNANI, Youssef L.; PIERCE, Albert C.; BHISETTI, Govinda Rao; COTTRELL, Kevin M.; MARONE, Valerie Patent: WO2011/9084 A2, 2011 ; Location in patent: Page/Page column 389 ;

~%

(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline Structure

(4S)-1-(tert-Bu...

CAS#:364750-81-2

Literature: WO2012/18325 A1, ; Page/Page column 146 ; WO 2012/018325 A1

~%

(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline Structure

(4S)-1-(tert-Bu...

CAS#:364750-81-2

Literature: Organic Letters, , vol. 12, # 13 p. 3018 - 3021

~%

(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline Structure

(4S)-1-(tert-Bu...

CAS#:364750-81-2

Literature: WO2012/39717 A1, ;

 Synonyms

(2S,4S)-4-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(2S,4S)-1-(tert-Butoxycarbonyl)-4-methylpyrrolidine-2-carboxylic acid
(4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline
(4S)-4-Methyl-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
1,2-Pyrrolidinedicarboxylic acid, 4-methyl-, 1-(1,1-dimethylethyl) ester, (2S,4S)-
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