2-Mercaptopyridine N-oxide sodium

Modify Date: 2024-01-01 22:40:30

2-Mercaptopyridine N-oxide sodium structure	Common Name	2-Mercaptopyridine N-oxide sodium
	CAS Number	3811-73-2	Molecular Weight	149.146
	Density	1.22	Boiling Point	109 °C
	Molecular Formula	C₅H₄NNaOS	Melting Point	-25 °C
	MSDS	Chinese USA	Flash Point	107.3ºC
	Symbol	GHS07	Signal Word	Warning

Use of 2-Mercaptopyridine N-oxide sodium

2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis[1].

Name	Sodium omadine
Synonym	More Synonyms

Description	2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC90 of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Debora L Campos, et al. Bactericidal Effect of pyridine-2-thiol 1-oxide Sodium Salt and Its Complex With Iron Against Resistant Clinical Isolates of Mycobacterium Tuberculosis. J Antibiot (Tokyo). 2020 Feb;73(2):120-124.

Density	1.22
Boiling Point	109 °C
Melting Point	-25 °C
Molecular Formula	C₅H₄NNaOS
Molecular Weight	149.146
Flash Point	107.3ºC
Exact Mass	148.991135
PSA	25.46000
LogP	1.02090
Water Solubility	54.7 g/100 mL

2-Mercaptopyridine N-oxide sodium MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT9000000

CHEMICAL NAME :: 2-Pyridinethiol, N-oxide, sodium salt

CAS REGISTRY NUMBER :: 3811-73-2

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H5-N-O-S.Na

MOLECULAR WEIGHT :: 150.16

WISWESSER LINE NOTATION :: T6NJ AO BS &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 428 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,883,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04703

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,693,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9403 No. of Facilities: 1876 (estimated) No. of Industries: 40 No. of Occupations: 42 No. of Employees: 69571 (estimated) No. of Female Employees: 7591 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R22;R36/38
Safety Phrases	S26-S36-S24/25-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT9000000
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections.

J. Virol. 83 , 58-64, (2009)

We have discovered two metal ion binding compounds, pyrithione (PT) and hinokitiol (HK), that efficiently inhibit human rhinovirus, coxsackievirus, and mengovirus multiplication. Early stages of virus...

Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.

Am. J. Respir. Cell. Mol. Biol. 41 , 69-75, (2009)

We recently reported that induction of metallothionein (MT) was critical in limiting nickel (Ni)-induced lung injury in intact mice. Nonetheless, the mechanism by which Ni induces MT expression is unc...

Functional alterations of human platelets following indium-111 labelling using different incubation media and labelling agents.

Eur. J. Nucl. Med. 18(5) , 326-31, (1991)

Human platelets were labelled in the absence or presence of plasma using indium-111 labelled oxine sulphate, tropolone or 2-mercaptopyridine-N-oxide (MPO). Under in vitro and in vivo conditions, plate...

Sodium Pyrithione

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MFCD01941547

2-Mercaptopyridine-1-oxide sodium salt

Pyrithione sodium salt

1-hydroxy-2(1H)-pyridinethione sodium salt

Sodi

Sodium 2-pyridinethiolate 1-oxide

Sodium pyridine-2-thiolate 1-oxide

1-hydroxy-1,2-dihydropyridine-2-thione sodium salt

2-Mercaptopyridine-N-Oxide,Sodium Salt

1-hydroxy-1H-pyridine-2-thione sodium salt

NaPT

2-Pyridinethiol-1-oxide sodium salt

Sodium-2-pyridinethiol-1-oxide

Sodium pyrithione(NaPT)

2-Pyridinethiol, 1-oxide, sodium salt (1:1)

N-Hydroxypyridinethione Sodium Salt

thione(reagent)

2-Mercaptopyridine N-Oxide Sodium Salt

EINECS 223-296-5

PYRITHIONE SODIUM

Sodium pyrithion

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Mercaptopyridine N-oxide sodium
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 2-Mercaptopyridine N-oxide sodium
Price: ￥118.0/5g ￥148.0/25g
Purity: 96.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: 2-Mercaptopyridine N-oxide sodium
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Sodium pyrithione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sodium omadine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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