17a-Hydroxypregnenolone

Modify Date: 2024-01-02 07:25:15

17a-Hydroxypregnenolone Structure
17a-Hydroxypregnenolone structure
Common Name 17a-Hydroxypregnenolone
CAS Number 387-79-1 Molecular Weight 334.493
Density 1.1±0.1 g/cm3 Boiling Point 468.1±40.0 °C at 760 mmHg
Molecular Formula C21H32O3 Melting Point 273℃
MSDS Chinese USA Flash Point 251.0±23.8 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

 Use of 17a-Hydroxypregnenolone


17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).

 Names

Name 17α-hydroxypregnenolone
Synonym More Synonyms

 17a-Hydroxypregnenolone Biological Activity

Description 17a-Hydroxypregnenolone is a pregnane steroid. 17a-Hydroxypregnenolone is a prohormone in the formation of dehydroepiandrosterone (DHEA).
Related Catalog
Target

Human Endogenous Metabolite

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 468.1±40.0 °C at 760 mmHg
Melting Point 273℃
Molecular Formula C21H32O3
Molecular Weight 334.493
Flash Point 251.0±23.8 °C
Exact Mass 334.250793
PSA 57.53000
LogP 3.46
Vapour Pressure 0.0±2.6 mmHg at 25°C
Index of Refraction 1.540
Storage condition ?20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5548000
CHEMICAL NAME :
Pregn-5-en-20-one, 3-beta,17-dihydroxy-
CAS REGISTRY NUMBER :
387-79-1
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H32-O3
MOLECULAR WEIGHT :
332.53
WISWESSER LINE NOTATION :
L E5 B666 LUTJ A1 E1 FV1 FQ OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
99600 ug/kg
SEX/DURATION :
male 48 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 5,45,1967
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
96 mg/kg
SEX/DURATION :
male 48 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,484,1973

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol
WGK Germany 3
RTECS TU5548000

 Articles26

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Substrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.

J. Biol. Chem. 288(23) , 17008-18, (2013)

The membrane heme protein cytochrome b5 (b5) can enhance, inhibit, or have no effect on cytochrome P450 (P450) catalysis, depending on the specific P450, substrate, and reaction conditions, but the st...

Serum concentrations of adrenal steroids and their precursors as a measure of maturity of adrenocortical function in very premature newborns.

Horm. Res. Paediatr. 74(5) , 358-64, (2010)

Relative adrenocortical insufficiency is often seen in sick premature newborns. As the human fetal adrenal cortex does not express the 3β-hydroxysteroid dehydrogenase (3β-HSD) enzyme before about 23 w...

Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma.

Endocr. J. 58(7) , 527-34, (2011)

Adrenocortical carcinoma (ACC) is a very rare malignant tumor with poor prognosis. To gain insight into the pathogenic significance of ACC, we studied clinicopathological features and gene expression ...

 Synonyms

MFCD00021129
Pregnan-2-one, 3,17-dihydroxy-
Hydroxypregnenolone
EINECS 206-862-6
HYDROXYPREGNENOLONE,17A
17a-Hydroxypregnolone
17alpha-Hydroxy
5-Pregnen-3.β.,17.α.-diol-20-one
17-OH PREG
3,17-Dihydroxypregnan-2-one
17-OH-pregnenolone
17A-HYDROXY PREGNENOLONE
17alpha-hydroxypregnenolone
17-Hydroxy Pregnenolone
17A-HYDROXYPREGENOLONE
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