ATV399

Modify Date: 2024-04-11 18:45:34

ATV399 Structure
ATV399 structure
Common Name ATV399
CAS Number 393834-37-2 Molecular Weight 465.522
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C24H23N3O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ATV399


ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS; inhibits cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose.

 Names

Name N-(4-{[2-(3-Pyridinyl)-1-piperidinyl]sulfonyl}phenyl)-1,3-benzodioxole-5-carboxamide
Synonym More Synonyms

 ATV399 Biological Activity

Description ATV399 (ATV-399) is a novel small molecule that dose-dependently reduces the cleaved caspase9 levels with IC50 of 3.3 uM, inhibits dimerization of iNOS; inhibits cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ and high glucose.
References References 1. Zhong L, et al. Br J Pharmacol. 2018 Jun 11. doi: 10.1111/bph.14388. View Related Products by Target Nitric Oxide Synthase (NOS)

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C24H23N3O5S
Molecular Weight 465.522
Exact Mass 465.135834
LogP 3.00
Index of Refraction 1.657

 Synonyms

1,3-Benzodioxole-5-carboxamide, N-[4-[[2-(3-pyridinyl)-1-piperidinyl]sulfonyl]phenyl]-
N-(4-{[2-(3-Pyridinyl)-1-piperidinyl]sulfonyl}phenyl)-1,3-benzodioxole-5-carboxamide
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