T62

Modify Date: 2024-01-16 08:22:01

T62 structure	Common Name	T62
	CAS Number	40312-34-3	Molecular Weight	291.79600
	Density	1.337g/cm3	Boiling Point	527ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₄ClNOS	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	272.5ºC

Use of T62

Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

Name	(2-amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-(4-chlorophenyl)methanone
Synonym	More Synonyms

Description	Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Adenosine A1 receptor[1]
In Vivo	Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1]. Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery[1] Dosage: 0.3 μg, 0.5 μg, 1 μg, and 3 μg Administration: Intrathecal administration Result: Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
References	[1]. Obata H, et al. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May;100(5):1258-62. [2]. Li X, et al. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun;305(3):950-5. [3]. Soudijn W, et al. Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov Today. 2004 Sep 1;9(17):752-8.

Density	1.337g/cm3
Boiling Point	527ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄ClNOS
Molecular Weight	291.79600
Flash Point	272.5ºC
Exact Mass	291.04800
PSA	71.33000
LogP	4.67470
Index of Refraction	1.658

T62 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

(2-amino-4,5,6,...

CAS#:880359-28-4

~80%

T62

CAS#:40312-34-3

Literature: Baraldi, Pier Giovanni; Pavani, Maria Giovanna; Leung, Edward; Moorman, Allan R.; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Romagnoli, Romeo Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1402 - 1404

Cyclohexanone

CAS#:108-94-1

4-Chlorobenzoyl...

CAS#:4640-66-8

~46%

T62

CAS#:40312-34-3

Literature: Van Der Klein, Pieter A. M.; Kourounakis, Angeliki P.; IJzerman, Ad P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3629 - 3635

3-(4-chloro-3,5...

CAS#:880359-27-3

T62

CAS#:40312-34-3

4-chloro-3,5-di...

CAS#:860697-28-5

T62

CAS#:40312-34-3

Cyclohexanone

CAS#:108-94-1

T62

CAS#:40312-34-3

Precursor 5
CAS#:880359-28-4 (2-amino-4,5,6,... CAS#:108-94-1 Cyclohexanone CAS#:4640-66-8 4-Chlorobenzoyl... CAS#:880359-27-3 3-(4-chloro-3,5...
CAS#:860697-28-5 4-chloro-3,5-di...
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism.

J. Pharmacol. Exp. Ther. 305 , 950-955, (2003)

Activation of adenosine A1 receptors by endogenous adenosine or synthetic agonists produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory a...

Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.

Anesthesiology 100(4) , 956-61, (2004)

The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pa...

Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.

Drug Discov. Today 9 , 752-758, (2004)

Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or...

2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene

UNII-9Q765ZIF8L

(2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone

T62

(2-amino-4,5,6,7-tetrahydro-1-benzothien-3-yl)(4-chlorophenyl)methanone

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: T62
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: T62
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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T62

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