Mitomycin A

Modify Date: 2024-01-02 11:53:01

Mitomycin A Structure
Mitomycin A structure
 Common Name Mitomycin A
CAS Number 4055-39-4 Molecular Weight 349.34
Density 1.5g/cm3 Boiling Point 587.4ºC at 760 mmHg
Molecular Formula C16H19N3O6 Melting Point 159-161ºC (dec)
MSDS N/A Flash Point 309.1ºC

 Use of Mitomycin A


Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer[1].

 Names

Name mitomycin A
Synonym More Synonyms

 Mitomycin A Biological Activity

Description Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer[1].
Related Catalog
References

[1]. van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986 Aug;172(1-2):120-7.  

 Chemical & Physical Properties

Density 1.5g/cm3
Boiling Point 587.4ºC at 760 mmHg
Melting Point 159-161ºC (dec)
Molecular Formula C16H19N3O6
Molecular Weight 349.34
Flash Point 309.1ºC
Exact Mass 349.12700
PSA 130.10000
LogP 0.00350
Vapour Pressure 8.83E-14mmHg at 25°C
Index of Refraction 1.638

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN1050000
CAS REGISTRY NUMBER :
4055-39-4
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H19-N3-O6
MOLECULAR WEIGHT :
349.38
WISWESSER LINE NOTATION :
T D3 B556 BN EM JV MVTTT&J GO1 H1OVZ KO1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Phage inhibition capacity
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
3 ug/L
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,767,1977

 Synthetic Route

(8aS)-8a-bromoalbomitomycin A structure

(8aS)-8a-bromoa...

CAS#:132732-87-7

~0%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

albomitomycin A structure

albomitomycin A

CAS#:110934-24-2

Literature: Kasai; Kono; Ikeda; Yoda; Hirayama Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7296 - 7299
Mitomycin C structure

Mitomycin C

CAS#:50-07-7

~81%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Kanda; Kasai Journal of Organic Chemistry, 1990 , vol. 55, # 8 p. 2515 - 2518
diazomethane structure

diazomethane

CAS#:186581-53-3

Azirino[2',3'_3,4]pyrrolo[1,2-.α.]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-hydroxy-8-(hydroxymethyl)-8a-methoxy-5-methyl-, 8-carbamate structure

Azirino[2',3'_3...

CAS#:7041-61-4

~51%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Sami, Salah M.; Iyengar, Bhashyam S.; Remers, William A.; Bradner, William T. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 168 - 173
Methanol structure

Methanol

CAS#:67-56-1

1a-acetyl-7-demethoxy-6,7-dihydro-7,7-(ethylenedioxy)-6-(phenylselenyl)mitomycin A structure

1a-acetyl-7-dem...

CAS#:122644-74-0

~66%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Arai, Hitoshi; Kasai, Masaji Journal of Organic Chemistry, 1993 , vol. 58, # 15 p. 4151 - 4152
Azirino[2',3'_3,4]pyrrolo[1,2-.α.]indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-6-hydroxy-8-(hydroxymethyl)-8a-methoxy-5-methyl-, 8-carbamate structure

Azirino[2',3'_3...

CAS#:7041-61-4

N/A structure

N/A

CAS#:20667-76-9

~48%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Vyas; Benigni; Partyka; Doyle Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4307 - 4309
N/A structure

N/A

CAS#:20667-76-9

Mitomycin C structure

Mitomycin C

CAS#:50-07-7

~%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Subramaniam; Kohn Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 10519 - 10526
(8aS)-8a-bromoalbomitomycin A structure

(8aS)-8a-bromoa...

CAS#:132732-87-7

~%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Kasai; Kono; Ikeda; Yoda; Hirayama Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7296 - 7299
Sodium Methylate structure

Sodium Methylate

CAS#:124-41-4

N/A structure

N/A

CAS#:128583-70-0

~58%

Mitomycin A Structure

Mitomycin A

CAS#:4055-39-4

Literature: Furuhata; Komiyama; Takeda; Takayanagi; Torii; Mishima; Ogura; Hata Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 10 p. 2651 - 2654

 Synonyms

[(1aS,8S,8aR,8bS)-6,8a-Dimethoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2,3,4]pyrrolo[1,2-a]indol-8-yl]methyl Carbamate
mitomycin-A
Mitomycin A
(1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-6,8a-dimethoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
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