(4-Benzyl-2-morpholinyl)methanol

Modify Date: 2024-01-08 19:19:35

(4-Benzyl-2-morpholinyl)methanol Structure
(4-Benzyl-2-morpholinyl)methanol structure
Common Name (4-Benzyl-2-morpholinyl)methanol
CAS Number 40987-24-4 Molecular Weight 207.269
Density 1.1±0.1 g/cm3 Boiling Point 303.2±27.0 °C at 760 mmHg
Molecular Formula C12H17NO2 Melting Point N/A
MSDS USA Flash Point 137.2±23.7 °C

 Names

Name 4-Benzyl-2-(hydroxymethyl)morpholine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 303.2±27.0 °C at 760 mmHg
Molecular Formula C12H17NO2
Molecular Weight 207.269
Flash Point 137.2±23.7 °C
Exact Mass 207.125931
PSA 32.70000
LogP 0.76
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.549
Storage condition 2-8°C

 MSDS

Name: (4-Benzyl-1 4-oxazinan-2-yl)methanol 97% Material Safety Data Sheet
Synonym: N-Benzyl-(3-hydroxymethyl)morpholine
CAS: 40987-24-4
Section 1 - Chemical Product MSDS Name:(4-Benzyl-1 4-oxazinan-2-yl)methanol 97% Material Safety Data Sheet
Synonym:N-Benzyl-(3-hydroxymethyl)morpholine

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
40987-24-4 (4-Benzyl-1,4-oxazinan-2-yl)methanol 97 unlisted
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 40987-24-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Viscous liquid
Color: colorless
Odor: characteristic odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 114 - 116 deg C @0.05mmHg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C12H17NO2
Molecular Weight: 207

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Bases, acids, oxidizing agents, acid chlorides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 40987-24-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
(4-Benzyl-1,4-oxazinan-2-yl)methanol - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 40987-24-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 40987-24-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 40987-24-4 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi
Risk Phrases 41
Safety Phrases 24/25
RIDADR 1760.0

 Synthetic Route

~70%

(4-Benzyl-2-morpholinyl)methanol Structure

(4-Benzyl-2-mor...

CAS#:40987-24-4

Literature: SANOFI; Brollo, Maurice; Carry, Jean-Christophe; Certal, Victor; Didier, Eric; Doerflinger, Gilles; EL Ahmad, Youssef; Filoche-Romme, Bruno; Halley, Frank; Karlsson, Karl Andreas; Schio, Laurent; Thompson, Fabienne Patent: US2013/274253 A1, 2013 ; Location in patent: Paragraph 1825-1826 ;

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(4-Benzyl-2-morpholinyl)methanol Structure

(4-Benzyl-2-mor...

CAS#:40987-24-4

Literature: ABBOTT LABORATORIES Patent: US2010/63022 A1, 2010 ; Location in patent: Page/Page column 29 ; US 20100063022 A1

~24%

(4-Benzyl-2-morpholinyl)methanol Structure

(4-Benzyl-2-mor...

CAS#:40987-24-4

Literature: Henegar, Kevin E. Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3662 - 3665

~%

(4-Benzyl-2-morpholinyl)methanol Structure

(4-Benzyl-2-mor...

CAS#:40987-24-4

Literature: Dobrev, Alexander; Nechev, Lubomir; Ivanov, Christo; Bon, Maryse Journal of Chemical Research, Miniprint, 1999 , # 3 p. 1001 - 1047

~%

(4-Benzyl-2-morpholinyl)methanol Structure

(4-Benzyl-2-mor...

CAS#:40987-24-4

Literature: SANOFI; Brollo, Maurice; Carry, Jean-Christophe; Certal, Victor; Didier, Eric; Doerflinger, Gilles; EL Ahmad, Youssef; Filoche-Romme, Bruno; Halley, Frank; Karlsson, Karl Andreas; Schio, Laurent; Thompson, Fabienne Patent: US2013/274253 A1, 2013 ;

~%

(4-Benzyl-2-morpholinyl)methanol Structure

(4-Benzyl-2-mor...

CAS#:40987-24-4

Literature: SANOFI; Brollo, Maurice; Carry, Jean-Christophe; Certal, Victor; Didier, Eric; Doerflinger, Gilles; EL Ahmad, Youssef; Filoche-Romme, Bruno; Halley, Frank; Karlsson, Karl Andreas; Schio, Laurent; Thompson, Fabienne Patent: US2013/274253 A1, 2013 ;

 Synonyms

(4-Benzyl-1,4-oxazinan-2-yl)methanol
2-Hydroxymethyl-4-benzylmorpholine
(4-Benzyl-2-morpholinyl)methanol
MFCD02682009
(4-benzylmorpholin-2-yl)methanol
2-Morpholinemethanol, 4-(phenylmethyl)-
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