Amitifadine

Modify Date: 2024-04-02 21:54:26

Amitifadine structure	Common Name	Amitifadine
	CAS Number	410074-73-6	Molecular Weight	228.118
	Density	1.4±0.1 g/cm3	Boiling Point	324.4±37.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₁Cl₂N	Melting Point	N/A
	MSDS	N/A	Flash Point	150.0±26.5 °C

Use of Amitifadine

A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg. Depression Phase 3 Clinical

Name	Amitifadine
Synonym	More Synonyms

Description	A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively; reduces the duration of immobility in the forced swim test in rats with an oral minimum effective dose (MED) of 5 mg/kg. Depression Phase 3 Clinical
References	References 1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. 2. Warnock KT, et al. Pharmacol Biochem Behav. 2012 Nov;103(1):111-8. View Related Products by Target Monoamine Transporter Depression

Density	1.4±0.1 g/cm3
Boiling Point	324.4±37.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₁Cl₂N
Molecular Weight	228.118
Flash Point	150.0±26.5 °C
Exact Mass	227.026855
LogP	2.57
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.622