Disodium 2'-deoxy-5'-O-phosphonatouridine

Modify Date: 2024-01-02 14:59:16

Disodium 2'-deoxy-5'-O-phosphonatouridine structure	Common Name	Disodium 2'-deoxy-5'-O-phosphonatouridine
	CAS Number	42155-08-8	Molecular Weight	352.146
	Density	1.742 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁N₂Na₂O₈P	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of Disodium 2'-deoxy-5'-O-phosphonatouridine

2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].

Name	2′-Deoxyuridine 5′-mono-phos-phate disodium salt
Synonym	More Synonyms

Description	2'-Deoxyuridine 5'-monophosphate disodium is reductively methylated to dTMP (2'-deoxythymidine 5'-monophosphate) by bisubstrate enzyme thymidylate synthase (TS). dTMP is a nucleotide required for DNA synthesis[1].
Related Catalog	Research Areas >> Metabolic Disease
References	[1]. Zachary Newby, et al. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20;45(24):7415-28.

Density	1.742 g/cm3
Molecular Formula	C₉H₁₁N₂Na₂O₈P
Molecular Weight	352.146
Exact Mass	352.004852
PSA	166.55000
Storage condition	−20°C

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn,Xi
Risk Phrases	R22
Safety Phrases	26-36-37/39
RIDADR	NONH for all modes of transport
WGK Germany	3

Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877 , 2937-2944, (2009)

To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography–tandem mass spectro...

Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX.

Proc. Natl. Acad. Sci. U. S. A. 110(22) , 8924-9, (2013)

In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride dono...

Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase.

J. Neurosci. 28 , 7219-7230, (2008)

Folate deficiency and resultant increased homocysteine levels have been linked experimentally and epidemiologically with neurodegenerative conditions like stroke and dementia. Moreover, folate deficie...

5'-Uridylic acid, 2'-deoxy-, sodium salt (1:2)

2'-Deoxyuridine 5'-monophosphate disodium salt

EINECS 255-687-1

Disodium 2'-deoxy-5'-O-phosphonatouridine

MFCD00065282

2'-Deoxyuridine 5'-mono-phos-phate disodium salt