Flunixin Meglumine

Modify Date: 2024-01-02 12:54:19

Flunixin Meglumine Structure
Flunixin Meglumine structure
 Common Name Flunixin Meglumine
CAS Number 42461-84-7 Molecular Weight 491.458
Density 1.403 g/cm3 Boiling Point 378.7ºC at 760 mmHg
Molecular Formula C21H28F3N3O7 Melting Point 136-138ºC
MSDS Chinese USA Flash Point 182.8ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Flunixin Meglumine


Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Target: COXFlunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when compared with these signs in saline solution-treated controls [1]. Flunixin meglumine was selective inhibitor of COX-1. Carprofen inhibited LPS-induction of iNOS. Carprofen and, to a lesser degree, flunixin meglumine had inhibitory effects on NFκB activation [2].

 Names

Name flunixin meglumine
Synonym More Synonyms

 Flunixin Meglumine Biological Activity

Description Flunixin Meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Target: COXFlunixin meglumine is a potent, non-narcotic, non-steroidal analgesic agent with anti-inflammatory and antipyretic activity. It is a potent inhibitor of the enzyme cyclooxygenase. Flunixin meglumine therapy significantly (P less than or equal to 0.05) reduced rectal temperatures and quarter signs of inflammation and improved clinically graded depression when compared with these signs in saline solution-treated controls [1]. Flunixin meglumine was selective inhibitor of COX-1. Carprofen inhibited LPS-induction of iNOS. Carprofen and, to a lesser degree, flunixin meglumine had inhibitory effects on NFκB activation [2].
Related Catalog
Target

COX-2:0.4 nM (IC50)

COX-1:17 nM (IC50)

References

[1]. Cheng Z, et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998 Aug;22(4):353-66.

[2]. Bryant, C.E., B.A. Farnfield, and H.J. Janicke, Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res, 2003. 64(2): p. 211-5.

 Chemical & Physical Properties

Density 1.403 g/cm3
Boiling Point 378.7ºC at 760 mmHg
Melting Point 136-138ºC
Molecular Formula C21H28F3N3O7
Molecular Weight 491.458
Flash Point 182.8ºC
Exact Mass 491.187927
PSA 175.40000
LogP 0.95620
Storage condition 0-6°C
Water Solubility H2O: freely soluble | soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LZ4367000
CHEMICAL NAME :
D-Glucitol, 1-deoxy-1-(methylamino)-, 2-((2-methyl-3-(trifluoromethyl)phenyl)amino)-3- pyridinecarboxylate (salt)
CAS REGISTRY NUMBER :
42461-84-7
LAST UPDATED :
199403
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H11-F3-N2-O2.C7-H17-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
39600 ug/kg/12D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 202,71,1993

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LZ4367000

 Articles62

More Articles
Pharmacokinetics and effects on thromboxane B2 production following intravenous administration of flunixin meglumine to exercised thoroughbred horses.

J. Vet. Pharmacol. Ther. 38 , 313-20, (2015)

Flunixin meglumine is commonly used in horses for the treatment of musculoskeletal injuries. The current ARCI threshold recommendation is 20 ng/mL when administered at least 24 h prior to race time. I...

Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.

J. Neurosci. 35(1) , 96-111, (2015)

In Parkinson's disease, long-term dopamine replacement therapy is complicated by the appearance of L-DOPA-induced dyskinesia (LID). One major hypothesis is that LID results from an aberrant transcript...

Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44.

Elife 4 , e06434, (2015)

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-prof...

 Synonyms

Flunixin meglumine
MFCD01725419
2-{[2-Methyl-3-(trifluoromethyl)phenyl]amino}nicotinic acid - 1-deoxy-1-(methylamino)-D-glucitol (1:1)
EINECS 255-836-0
3-pyridinecarboxylic acid, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-, compd. with D-glucitol, 1-deoxy-1-(methylamino)- (1:1)
FLUNIXIN N-METHYLGLUCAMINE
2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid meglumine salt Banamine
2-{[2-methyl-3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid - 1-deoxy-1-(methylamino)-D-glucitol (1:1)
Flunixin (meglumine)
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