N-METHYL-2-PHTHALIMIDOGLUTARIMIDE

Modify Date: 2024-01-26 12:59:42

N-METHYL-2-PHTHALIMIDOGLUTARIMIDE Structure
N-METHYL-2-PHTHALIMIDOGLUTARIMIDE structure
Common Name N-METHYL-2-PHTHALIMIDOGLUTARIMIDE
CAS Number 42472-93-5 Molecular Weight 272.25600
Density 1.457g/cm3 Boiling Point 477ºC at 760 mmHg
Molecular Formula C14H12N2O4 Melting Point N/A
MSDS N/A Flash Point 232ºC

 Names

Name 2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.457g/cm3
Boiling Point 477ºC at 760 mmHg
Molecular Formula C14H12N2O4
Molecular Weight 272.25600
Flash Point 232ºC
Exact Mass 272.08000
PSA 74.76000
LogP 0.30580
Index of Refraction 1.64

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA5300000
CHEMICAL NAME :
Glutarimide, N-methyl-2-phthalimido-
CAS REGISTRY NUMBER :
42472-93-5
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H12-N2-O4
MOLECULAR WEIGHT :
272.28
WISWESSER LINE NOTATION :
T56 BVNVJ C- DT6VNVTJ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
670 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,721,1964 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
650 mg/kg
SEX/DURATION :
female 4-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,721,1964

 Synthetic Route

~68%

N-METHYL-2-PHTHALIMIDOGLUTARIMIDE Structure

N-METHYL-2-PHTH...

CAS#:42472-93-5

Literature: Goosen; Laing; Plessis; Flynn Pharmaceutical Research, 2002 , vol. 19, # 1 p. 13 - 19

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

6-Methyl-2-phthalimido-glutarimid
methyl-thalidomide
Glutarimide,N-methyl-2-phthalimido
N-methyl thalidomide
2-Phthalimido-N-methyl-glutarimide
2-(1-methyl-2,6-dioxopiperidin-3-yl)-1h-isoindole-1,3(2h)-dione
N-Methyl-2-phthalimidoglutarimide
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