VU 0357121
Modify Date: 2024-01-21 14:08:27
VU 0357121 structure
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Common Name | VU 0357121 | ||
|---|---|---|---|---|
| CAS Number | 433967-28-3 | Molecular Weight | 305.319 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 338.7±42.0 °C at 760 mmHg | |
| Molecular Formula | C17H17F2NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 158.7±27.9 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of VU 0357121VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.IC50 Value: 33 nM(EC50)Target: mGluR5in vitro: VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. in vivo: |
| Name | 4-Butoxy-N-(2,4-difluorophenyl)benzamide |
|---|---|
| Synonym | More Synonyms |
| Description | VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.IC50 Value: 33 nM(EC50)Target: mGluR5in vitro: VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line. in vivo: |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 338.7±42.0 °C at 760 mmHg |
| Molecular Formula | C17H17F2NO2 |
| Molecular Weight | 305.319 |
| Flash Point | 158.7±27.9 °C |
| Exact Mass | 305.122742 |
| PSA | 38.33000 |
| LogP | 4.78 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.564 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: ≥18mg/mL |
| Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- |
| 4-Butoxy-N-(2,4-difluorophenyl)benzamide |
| 4-Butoxy-N-(2,4-difluorophenyl)-benzamide |
| VU 0357121 |
| cc-377 |
| VU-0357121 |
| VU0357121 |