2-Aminopurine

Modify Date: 2024-01-01 20:20:19

2-Aminopurine structure	Common Name	2-Aminopurine
	CAS Number	452-06-2	Molecular Weight	135.127
	Density	1.9±0.1 g/cm3	Boiling Point	328.2±25.0 °C at 760 mmHg
	Molecular Formula	C₅H₅N₅	Melting Point	280-282 °C(lit.)
	MSDS	Chinese USA	Flash Point	152.3±23.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of 2-Aminopurine

2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics[1][2].

Name	2-aminopurine
Synonym	More Synonyms

Description	2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	2-Aminopurine (2AP) is not valuable as afluorescent label because its fluorescence is highly quenched by stacking with the natural bases, when it is inserted in anoligonucleotide. However, it is this very susceptibility to interbase quenching that makes 2AP an exquisitely sensitivefluorescent probe of nucleic acid structure[1]. 2-Aminopurine differs from adenine (6-aminopurine) only in the position of the exocyclic amine group, and yet its fluorescence intensity is one thousand times that of adenine[1].
References	[1]. J M Jean, et al. 2-Aminopurine fluorescence quenching and lifetimes: role of base stacking. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):37-41. [2]. Dehong Tan, et al. Decreased glycation and structural protection properties of γ-glutamyl-S-allyl-cysteine peptide isolated from fresh garlic scales (Allium sativum L.). Nat Prod Res. 2015;29(23):2219-22.

Density	1.9±0.1 g/cm3
Boiling Point	328.2±25.0 °C at 760 mmHg
Melting Point	280-282 °C(lit.)
Molecular Formula	C₅H₅N₅
Molecular Weight	135.127
Flash Point	152.3±23.2 °C
Exact Mass	135.054489
PSA	80.48000
LogP	-1.33
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.954

2-Aminopurine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO7475000

CHEMICAL NAME :: Purine, 2-amino-

CAS REGISTRY NUMBER :: 452-06-2

LAST UPDATED :: 199612

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C5-H5-N5

MOLECULAR WEIGHT :: 135.15

WISWESSER LINE NOTATION :: T56 BN DM FN HNJ GZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 723 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 100 mg/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 78,5685,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22
Safety Phrases	S22-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UO7475000
HS Code	2933990090

2-Amino-6-chlor...

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2-Aminopurine

CAS#:452-06-2

Literature: Kusmierek, Jaroslaw; Czochralska, Barbara; Johansson, Nils Gunnar; Shugar, David Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 10 p. 701 - 707

Amipurimycin

CAS#:61991-08-0

~48%

2-Aminopurine

CAS#:452-06-2

Literature: Goto; Toya; Ohgi; Kondo Tetrahedron Letters, 1982 , vol. 23, # 12 p. 1271 - 1274

2-Methylthiopurine

CAS#:33512-51-5

~90%

2-Aminopurine

CAS#:452-06-2

Literature: Kos, Nico J.; Plas, Henk C. van der Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 2942 - 2945

6-Thioguanine

CAS#:154-42-7

2-Aminopurine

CAS#:452-06-2

Literature: Anufriev, M. A.; Ratsino, E. V.; Elagin, L. M.; Sokolov, L. B.; Komarov, E. V. J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 5 p. 1015 - 1019,884 - 887

(Z)-Methanimidi...

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2-Aminopurine

CAS#:452-06-2

Literature: Saladino, Raffaele; Botta, Giorgia; Delfino, Michela; Di Mauro, Ernesto Chemistry - A European Journal, 2013 , vol. 19, # 50 p. 16916 - 16922

2,4,5-Pyrimidin...

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dimethoxymethyl...

CAS#:14036-53-4

~59%

2-Aminopurine

CAS#:452-06-2

Literature: Tisler, Miha; Stanovnik, Branko; Zrimsek, Zdenka Heterocycles, 1982 , vol. 17, p. 405 - 411

[(2S,5R)-5-(2-a...

CAS#:107550-74-3

N/A

CAS#:122999-44-4

2-Aminopurine

CAS#:452-06-2

Literature: Nair, Vasu; Buenger, Greg S. Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3695 - 3697

9H-Purin-2-amin...

CAS#:3616-24-8

N/A

CAS#:18620-60-5

2-Aminopurine

CAS#:452-06-2

Literature: Ratsep, Peter C.; Pless, Reynaldo C. Journal of Organic Chemistry, 1988 , vol. 53, # 14 p. 3241 - 3246

Precursor 8
CAS#:10310-21-1 2-Amino-6-chlor... CAS#:61991-08-0 Amipurimycin CAS#:33512-51-5 2-Methylthiopurine CAS#:154-42-7 6-Thioguanine
CAS#:77287-34-4 (Z)-Methanimidi... CAS#:3546-50-7 2,4,5-Pyrimidin... CAS#:107550-74-3 [(2S,5R)-5-(2-a... CAS#:3616-24-8 9H-Purin-2-amin...
DownStream 6
CAS#:107550-74-3 [(2S,5R)-5-(2-a... CAS#:4546-54-7 2-amino-9-(β-D-... CAS#:104227-87-4 Famciclovir CAS#:3616-24-8 9H-Purin-2-amin...
CAS#:114810-83-2 2-[(2-aminopuri... CAS#:84408-37-7 Desciclovir

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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China
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DC Chemicals Limited
China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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