GW6604
Modify Date: 2024-01-14 17:49:25
GW6604 structure
|
Common Name | GW6604 | ||
|---|---|---|---|---|
| CAS Number | 452342-37-9 | Molecular Weight | 298.341 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 505.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H14N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 272.5±16.5 °C | |
Use of GW6604GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1]. |
| Name | 2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine |
|---|---|
| Synonym | More Synonyms |
| Description | GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1]. |
|---|---|
| Related Catalog | |
| In Vitro | GW-6604(0-10 μM, )抑制 HepG2 细胞中 TGF-β 诱导的 PAI-1 转录和分泌的 IC50 值为 500 nM，有效阻断了 Smad 依赖性反应[1]。 |
| In Vivo | GW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks)在 SD 大鼠急性 DMN 模型中，依赖性地抑制肝脏 COL IA1 过度表达，使其表达降低了 80%。保持了正常的肝脏重量，有效减少了肝纤维化以及增加基质退化[1]。 |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 505.2±50.0 °C at 760 mmHg |
| Molecular Formula | C19H14N4 |
| Molecular Weight | 298.341 |
| Flash Point | 272.5±16.5 °C |
| Exact Mass | 298.121857 |
| PSA | 54.46000 |
| LogP | 3.18 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.650 |
| Pyridine, 2-phenyl-4-[5-(2-pyridinyl)-1H-pyrazol-4-yl]- |
| 2-phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine |
| gw-6604 |
| 2-Phenyl-4-[5-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine |
| unii-273g6sn31h |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: GW-6604
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: GW-6604
- Price: $504.0/100mg $990.0/250mg $1800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: GW6604
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 2-phenyl-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridine
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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