2,5-DiMethyl Celecoxib
2,5-DiMethyl Celecoxib structure
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Common Name | 2,5-DiMethyl Celecoxib | ||
|---|---|---|---|---|
| CAS Number | 457639-26-8 | Molecular Weight | 395.399 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 516.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H16F3N3O2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 266.3±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of 2,5-DiMethyl Celecoxib2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2. It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) and reduces prostaglandin E2 (PGE2) production in HeLa, A549, and HCA-7 cells. It inhibits proliferation of drug-sensitive RPMI8226 and multidrug-resistant 8226/Dox40 multiple myeloma cells, as well as increases the rate of apoptosis when used at concentrations of 20 and 30 μM. 2,5-dimethyl Celecoxib reduces the expression of survivin, cyclin A, cyclin B, MEK1, and MEK2 in 8226/Dox40 cells. The antiproliferative effect of 2,5-dimethyl celecoxib is independent of mPGES-1 inhibition. |
| Name | 2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 516.7±60.0 °C at 760 mmHg |
| Molecular Formula | C18H16F3N3O2S |
| Molecular Weight | 395.399 |
| Flash Point | 266.3±32.9 °C |
| Exact Mass | 395.091522 |
| PSA | 86.36000 |
| LogP | 4.67 |
| Appearance of Characters | white to beige |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.600 |
| Storage condition | room temp |
| Water Solubility | DMSO: soluble20mg/mL, clear |
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SERCaMP: a carboxy-terminal protein modification that enables monitoring of ER calcium homeostasis.
Mol. Biol. Cell 25(18) , 2828-39, (2014) Endoplasmic reticulum (ER) calcium homeostasis is disrupted in diverse pathologies, including neurodegeneration, cardiovascular diseases, and diabetes. Temporally defining calcium dysregulation during... |
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COX-2- and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon cancer cells.
Exp. Cell Res. 330(2) , 451-9, (2014) In the present study, we investigated whether celecoxib could induce the expression of NKG2D ligands in clonogenic colon cancer cells, and increase their susceptibility to NK cell-mediated cell death.... |
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Celecoxib exerts antitumor effects in canine mammary tumor cells via COX‑2‑independent mechanisms.
Int. J. Oncol. 46(3) , 1393-404, (2015) Celecoxib plays antitumor roles via multiple mechanisms in a variety of human cancers. The aim of this study was to clarify the mechanism of action of celecoxib in canine mammary tumors. We examined t... |
| 2,5-Dimethyl Celecoxib |
| 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide |
| 4-[5-(2,5-Dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide |
| Benzenesulfonamide, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]- |
| 2,5-Dimethyl-celecoxib |