Eact
Modify Date: 2024-01-08 22:36:52
Eact structure
|
Common Name | Eact | ||
|---|---|---|---|---|
| CAS Number | 461000-66-8 | Molecular Weight | 428.50100 | |
| Density | 1.237±0.06 g/cm3(Predicted) | Boiling Point | 595.9±60.0 ℃(Predicted) | |
| Molecular Formula | C22H24N2O5S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of EactEact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1]. |
| Name | N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)-3,4,5-trimethoxybenzeneacetamide |
|---|---|
| Synonym | More Synonyms |
| Description | Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1]. |
|---|---|
| In Vitro | Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC50 of 11.6 ± 2.5 μM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels[1]. |
| References |
| Density | 1.237±0.06 g/cm3(Predicted) |
|---|---|
| Boiling Point | 595.9±60.0 ℃(Predicted) |
| Molecular Formula | C22H24N2O5S |
| Molecular Weight | 428.50100 |
| Exact Mass | 428.14100 |
| PSA | 98.36000 |
| LogP | 4.12910 |
| Storage condition | 2-8°C |
| MFCD03115431 |