Hexane-1,6-diyldiphosphonic acid

Modify Date: 2024-01-08 17:23:14

Hexane-1,6-diyldiphosphonic acid Structure
Hexane-1,6-diyldiphosphonic acid structure
Common Name Hexane-1,6-diyldiphosphonic acid
CAS Number 4721-22-6 Molecular Weight 246.13500
Density N/A Boiling Point N/A
Molecular Formula C6H16O6P2 Melting Point 206 °C
MSDS N/A Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Hexane-1,6-diyldiphosphonic acid


Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 6-phosphonohexylphosphonic acid
Synonym More Synonyms

 Hexane-1,6-diyldiphosphonic acid Biological Activity

Description Hexane-1,6-diyldiphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Melting Point 206 °C
Molecular Formula C6H16O6P2
Molecular Weight 246.13500
Exact Mass 246.04200
PSA 134.68000
LogP 0.90220

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P280-P305 + P351 + P338-P337 + P313
Hazard Codes C
RIDADR NONH for all modes of transport

 Synonyms

1,6-hexylenediphosphonic acid
1,6-HEXYLENEBISPHOSPHONIC ACID
hexane-1,6-diylbisphosphonic acid
hexane-1,6-diyldiphosphonic acid
1,6-Hexanebisphosphonic acid
1,6-Diphosphono-hexan
1,6-hexanediphosphonic acid
hexane-1,6-bisphosphonic acid