Bergaptol
Bergaptol structure
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Common Name | Bergaptol | ||
|---|---|---|---|---|
| CAS Number | 486-60-2 | Molecular Weight | 202.163 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 311.9±11.0 °C at 760 mmHg | |
| Molecular Formula | C11H6O4 | Melting Point | 287-290ºC | |
| MSDS | Chinese USA | Flash Point | 142.4±19.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of BergaptolBergaptolA hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.target: CYP3A4 [1]IC50: 24.92 [1]For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2] |
| Name | bergaptol |
|---|---|
| Synonym | More Synonyms |
| Description | BergaptolA hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties.target: CYP3A4 [1]IC50: 24.92 [1]For in vivo enzyme activity analysis, 100 μM bergaptol was added to the cultures for an additional 24 h at 37°C. After centrifugation, the supernatant was used to measure the bergapten yield by high performance liquid chromatography (HPLC).[2] |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 311.9±11.0 °C at 760 mmHg |
| Melting Point | 287-290ºC |
| Molecular Formula | C11H6O4 |
| Molecular Weight | 202.163 |
| Flash Point | 142.4±19.3 °C |
| Exact Mass | 202.026611 |
| PSA | 63.58000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.711 |
| Storage condition | 2-8°C |
|
~85%
Bergaptol CAS#:486-60-2 |
| Literature: Bellevue III, Frank H.; Woster, Patrick M.; Edwards, David J.; He, Kan; Hollenberg, Paul F. Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 20 p. 2593 - 2598 |
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~%
Bergaptol CAS#:486-60-2 |
| Literature: Kozawa; Fukumoto; Matsuyama; Baba Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2712 - 2717 |
|
~%
Bergaptol CAS#:486-60-2 |
| Literature: Kozawa; Fukumoto; Matsuyama; Baba Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2712 - 2717 |
|
~%
Bergaptol CAS#:486-60-2 |
| Literature: El-Tawil, B.A.H.; Baghlaf, A.O.; Barbood, S.O. Pharmazie, 1980 , vol. 35, # 8 p. 503 |
|
~%
Bergaptol CAS#:486-60-2 |
| Literature: Gu; Zhang; Yang; Hattori; Namba Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2498 - 2502 |
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~%
Bergaptol CAS#:486-60-2 |
| Literature: Abyshev, A. Z.; Abyshev, D. Z. Chemistry of Natural Compounds, 1983 , vol. 19, # 6 p. 668 - 672 Khimiya Prirodnykh Soedinenii, 1983 , # 6 p. 704 - 709 |
|
~%
Bergaptol CAS#:486-60-2 |
| Literature: Cesar, Thais B.; Manthey, John A.; Myung, Kyung Journal of Natural Products, 2009 , vol. 72, # 9 p. 1702 - 1704 |
|
~%
Bergaptol CAS#:486-60-2 |
| Literature: Spaeth; Kainrath Chemische Berichte, 1937 , vol. 70, p. 2274 |
![7H-Furo[3,2-g][1]benzopyran-7-one, 4-[[3-[2-(3,3-dimethyloxiranyl)ethyl]-3-methyloxiranyl]methoxy] structure](https://image.chemsrc.com/caspic/374/89787-38-2.png)
| Precursor 8 | |
|---|---|
| DownStream 10 | |
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CAS#:87997-40-8
CAS#:483-36-3|
Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures
Food Chem. Toxicol. 68 , 257-66, (2014) • The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica arch... |
| 4-hydroxyfuranocoumarin |
| 5-Hydroxypsoralen |
| 4-hydroxyfuro[3,2-g]chromen-7-one |
| 4-Hydroxy7H-furo[3,2-g][1]benzopyran-7-one,4-Hydroxybergapten,5-Hydroxy-6,7-furanocoumarin |
| xanthotoxol |
| 5-Hydroxyfuranocoumarin |
| 7H-Furo[3,2-g][1]benzopyran-7-one, 4-hydroxy- |
| Psoralin,5-hydroxy |
| 4-Hydroxy-7H-furo[3,2-g]chromen-7-one |
| Bergaptol |
| 9-hydroxyfuranocoumarin |
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