Phillyrin

Modify Date: 2024-01-02 14:13:41

Phillyrin Structure
Phillyrin structure
 Common Name Phillyrin
CAS Number 487-41-2 Molecular Weight 534.552
Density 1.4±0.1 g/cm3 Boiling Point 730.4±60.0 °C at 760 mmHg
Molecular Formula C27H34O11 Melting Point N/A
MSDS Chinese USA Flash Point 395.5±32.9 °C

 Use of Phillyrin


Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1].

 Names

Name forsythin
Synonym More Synonyms

 Phillyrin Biological Activity

Description Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1].
Related Catalog
Target

CYP1A2; CYP2D1[1]

In Vitro Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS protein significantly in HepG2 cells[1]. Phillyrin (1–5 μM; pretreatment 1 hour; 24 hours) inhibits high glucose-induced FAS mRNA expression by suppressing SREBP-1c activation in human HepG2 hepatocytes[1]. RT-PCR[1] Cell Line: Human HepG2 hepatocyte cells Concentration: 1 μM; 2.5 μM; 5 μM Incubation Time: 24 hours Result: Reduced FAS and SREBP-1c mRNA expression.
References

[1]. Cheng Y, et al. Effects of phillyrin and forsythoside A on rat cytochrome P450 activities in vivo and in vitro. Xenobiotica. 2017 Apr;47(4):297-303.

[2]. Do MT, et al. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food Chem. 2013 Jan 15;136(2):415-25.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 730.4±60.0 °C at 760 mmHg
Molecular Formula C27H34O11
Molecular Weight 534.552
Flash Point 395.5±32.9 °C
Exact Mass 534.210083
PSA 145.53000
LogP 0.08
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.596

 Safety Information

Hazard Codes C
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29389090

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

β-D-Glucopyranoside, 4-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl
Pillyrin
Chionanthin
4-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl β-D-glucopyranoside
PHILLYRIN
Phillyroside
phyllyrin
[1S-(1a,3aa,4b,6aa)]-4-[4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl-b-D-glucopyranoside
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