KRP-203 hydrochloride
Modify Date: 2024-01-19 17:46:15
KRP-203 hydrochloride structure
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Common Name | KRP-203 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 509088-69-1 | Molecular Weight | 480.447 | |
| Density | N/A | Boiling Point | 657.1ºC at 760 mmHg | |
| Molecular Formula | C24H27Cl2NO3S | Melting Point | 199-200ºC (DEC.) | |
| MSDS | N/A | Flash Point | 351.2ºC | |
Use of KRP-203 hydrochlorideMocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2]. |
| Name | 2-amino-2-[2-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]ethyl]propane-1,3-diol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2]. |
|---|---|
| Target |
S1PR1[1] |
| In Vivo | Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R−/− Mice[1]. Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2]. Animal Model: Inbred male DA (MHC haplotype: RT1a) rats[2] Dosage: 0.1 and 1 mg/kg Administration: Orally; daily; for 100 days Result: Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts. |
| References |
| Boiling Point | 657.1ºC at 760 mmHg |
|---|---|
| Melting Point | 199-200ºC (DEC.) |
| Molecular Formula | C24H27Cl2NO3S |
| Molecular Weight | 480.447 |
| Flash Point | 351.2ºC |
| Exact Mass | 479.108856 |
| PSA | 101.01000 |
| LogP | 6.18720 |
| 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1) |
| KRP-203 hydrochloride |
| 2-Amino-2-[2-(4-{[3-(benzyloxy)phenyl]sulfanyl}-2-chlorophenyl)ethyl]-1,3-propanediol hydrochloride (1:1) |
| KRP-203 |
| 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride |