L-Hydroxyproline

Modify Date: 2024-01-01 20:04:20

L-Hydroxyproline Structure
L-Hydroxyproline structure
 Common Name L-Hydroxyproline
CAS Number 51-35-4 Molecular Weight 131.130
Density 1.4±0.1 g/cm3 Boiling Point 355.2±42.0 °C at 760 mmHg
Molecular Formula C5H9NO3 Melting Point 273 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 168.6±27.9 °C

 Use of L-Hydroxyproline


L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

 Names

Name 4-hydroxy-L-proline
Synonym More Synonyms

 L-Hydroxyproline Biological Activity

Description L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro L-Hydroxyproline (Trans-4-hydroxy-L-proline;Trans-Hyp) has been widely used in medicine, biochemistry, food, cosmetic and other aspects of industry. Additionally, L-Hydroxyproline has also been found in the composition of some secondary metabolites such as actinomycins and echinocandins. L-Hydroxyproline is manufactured industrially most by acid hydrolysis of mammalian collagen because of its rich amount in the collagen[1].
References

[1]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 355.2±42.0 °C at 760 mmHg
Melting Point 273 °C (dec.)(lit.)
Molecular Formula C5H9NO3
Molecular Weight 131.130
Flash Point 168.6±27.9 °C
Exact Mass 131.058243
PSA 69.56000
LogP -1.84
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.540
Water Solubility 357.8 g/L (20 º C)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TW3586500
CHEMICAL NAME :
Proline, 4-hydroxy-, L-
CAS REGISTRY NUMBER :
51-35-4
LAST UPDATED :
199806
DATA ITEMS CITED :
1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TW3586500
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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 Synonyms

4-Hydroxyproline
(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate
Hydroxyproline
MFCD00064320
L-Hydroxyproline
trans-Lachnophyllol
trans-4-hydroxyproline
Proline, 4-hydroxy-, L-
trans-L-4-hydroxyproline
(2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
Proline, 4-hydroxy-
trans-4-Hydroxy-L-proline
dec-2t-ene-4,6-diyn-1-ol
L-trans-4-hydroxyproline
(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid
L-Proline, 4-hydroxy-, trans- (9CI)
L-Proline, 4-hydroxy-, (4R)-
Dec-2t-en-4,6-diin-1-ol
EINECS 200-091-9
rans-4-Hydroxy-L-proline
(-)-(2S,4R)-4-HYDROXYPROLINE
(2S,4R)-4-hydroxyproline
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
4-Hydroxy-2-pyrrolidinecarboxylic acid
(trans)-4-Hydroxy-L-proline
(2S,4R)-trans-4-hydroxyproline
(4R)-4-Hydroxy-L-proline
L-Proline, 4-hydroxy-, trans-
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid,Hyp
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