AR03

Modify Date: 2024-01-13 19:06:24

AR03 Structure
AR03 structure
Common Name AR03
CAS Number 510721-85-4 Molecular Weight 237.30
Density N/A Boiling Point N/A
Molecular Formula C15H15N3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AR03


AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].

 Names

Name 2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine
Synonym More Synonyms

 AR03 Biological Activity

Description AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].
Related Catalog
Target

IC50: 2.1 µM (Ape1)[1]

References

[1]. Aditi Bapat, et al. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. J Pharmacol Exp Ther. 2010 Sep 1;334(3):988-98.

 Chemical & Physical Properties

Molecular Formula C15H15N3
Molecular Weight 237.30
Exact Mass 237.12700
PSA 51.80000
LogP 3.87160

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2,4,9-Trimethyl-benzo[b][1,8]naphthyridin-5-ylamine
HMS2537D20
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