2-AMINOTHIAZOLE-5-CARBONITRILE

Modify Date: 2024-01-05 12:05:24

2-AMINOTHIAZOLE-5-CARBONITRILE Structure
2-AMINOTHIAZOLE-5-CARBONITRILE structure
Common Name 2-AMINOTHIAZOLE-5-CARBONITRILE
CAS Number 51640-52-9 Molecular Weight 125.15200
Density 1.45g/cm3 Boiling Point 330.4ºC at 760mmHg
Molecular Formula C4H3N3S Melting Point 185-187ºC
MSDS Chinese USA Flash Point 153.6ºC
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Names

Name 2-Amino-5-cyanothiazole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.45g/cm3
Boiling Point 330.4ºC at 760mmHg
Melting Point 185-187ºC
Molecular Formula C4H3N3S
Molecular Weight 125.15200
Flash Point 153.6ºC
Exact Mass 125.00500
PSA 90.94000
LogP 1.17818
Index of Refraction 1.636
Storage condition 2-8°C

 MSDS

Material Safety Data Sheet

Section1. Identification of the substance
2-Amino-5-cyanothiazole
Product Name:
Synonyms:2-Aminothiazole-5-carbonitrile

Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302:Harmful if swallowed
H318:Causes serious eye damage
P280:Wear protective gloves/protective clothing/eye protection/face protection
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing

Section3. Composition/information on ingredients.
Ingredient name:2-Amino-5-cyanothiazole
CAS number:51640-52-9

Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
This product should be handled only by, or under the close supervision of, those properly qualified
Handling:
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula: C4H3N3S
Molecular weight: 125.2

Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
UN Number:UN3439Class: 6.1Packing group: III
Proper shipping name: NITRILES, TOXIC, SOLID, N.O.S. (2-Amino-5-cyanothiazole)

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H318
Precautionary Statements P280-P305 + P351 + P338
Hazard Codes Xi
Risk Phrases 22-41
Safety Phrases 26-39
RIDADR NONH for all modes of transport
HS Code 2934100090

 Synthetic Route

~81%

2-AMINOTHIAZOLE-5-CARBONITRILE Structure

2-AMINOTHIAZOLE...

CAS#:51640-52-9

Literature: Institut Pasteur De Lille; Centre National De La Recherche Scientifique; Universite De Lille 2, Universite Du Droit Et De La Sante; Institut National De La Sante Et De La Recherche Medicale (Inserm) Patent: US2011/136823 A1, 2011 ; Location in patent: Page/Page column 43-44 ;

~95%

2-AMINOTHIAZOLE-5-CARBONITRILE Structure

2-AMINOTHIAZOLE...

CAS#:51640-52-9

Literature: ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2007/31745 A1, 2007 ; Location in patent: Page/Page column 102-103 ; WO 2007/031745 A1

~20%

2-AMINOTHIAZOLE-5-CARBONITRILE Structure

2-AMINOTHIAZOLE...

CAS#:51640-52-9

Literature: Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao Patent: US2010/87448 A1, 2010 ; Location in patent: Page/Page column 21 ;

~88%

2-AMINOTHIAZOLE-5-CARBONITRILE Structure

2-AMINOTHIAZOLE...

CAS#:51640-52-9

Literature: Francisco, Gerardo D.; Li, Zhong; Albright, J. Donald; Eudy, Nancy H.; Katz, Alan H.; Petersen, Peter J.; Labthavikul, Pornpen; Singh, Guy; Yang, Youjun; Rasmussen, Beth A.; Lin, Yang-I.; Mansour, Tarek S. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 235 - 238

~%

2-AMINOTHIAZOLE-5-CARBONITRILE Structure

2-AMINOTHIAZOLE...

CAS#:51640-52-9

Literature: Zhao, Matthew; Yin, Jingjun; Huffman, Mark A.; McNamara, James M. Tetrahedron, 2006 , vol. 62, # 6 p. 1110 - 1115

 Customs

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Synonyms

2-amino-1,3-thiazole-5-carbonitrile
2-Aminothiazole-5-carbonitrile
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