equilenin
equilenin structure
|
Common Name | equilenin | ||
|---|---|---|---|---|
| CAS Number | 517-09-9 | Molecular Weight | 266.33400 | |
| Density | 1.242g/cm3 | Boiling Point | 472.6ºC at 760mmHg | |
| Molecular Formula | C18H18O2 | Melting Point | 258-259° | |
| MSDS | USA | Flash Point | 200.9ºC | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
Use of equileninEquilenin is an equine estrogen found in the urine of pregnant mares. Equilenin is also a naturally fluorescent steroid, has high binding affinity for human sex steroid-binding protein (SBP). At 4 degrees C the equilibrium association constant is approximately 6 X 10(7) M-1. |
| Name | (13S,14S)-3-hydroxy-13-methyl-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthren-17-one |
|---|---|
| Synonym | More Synonyms |
| Density | 1.242g/cm3 |
|---|---|
| Boiling Point | 472.6ºC at 760mmHg |
| Melting Point | 258-259° |
| Molecular Formula | C18H18O2 |
| Molecular Weight | 266.33400 |
| Flash Point | 200.9ºC |
| Exact Mass | 266.13100 |
| PSA | 37.30000 |
| LogP | 3.94440 |
| Index of Refraction | 1.662 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302-H312-H319-H332 |
| Precautionary Statements | P210-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | F,Xn |
| Risk Phrases | 11-20/21/22-36 |
| Safety Phrases | 16-26-36-36/37 |
| RIDADR | UN 1648 3/PG 2 |
| Precursor 8 | |
|---|---|
| DownStream 3 | |
CAS#:3907-67-3
CAS#:2526-84-3
CAS#:2752-08-1
CAS#:6030-91-7
CAS#:474-86-2
CAS#:43085-97-8
CAS#:1423-97-8
CAS#:434-22-0
CAS#:53-16-7![(13S,14S)-13-methyl-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthrene-3,4,17-trione structure](https://image.chemsrc.com/caspic/258/170473-80-0.png)
CAS#:170473-80-0
CAS#:16680-48-1|
Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells.
Chem. Res. Toxicol. 22(6) , 1129-36, (2009) Estrogen-DNA adducts are potential biomarkers for assessing cancer risk and progression in estrogen-dependent cancer. 4-Hydroxyequilenin (4-OHEN), the major catechol metabolite of equine estrogens pre... |
|
|
Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.
Endocrinology 148(10) , 4793-802, (2007) 4-Methoxyequilenin (4-MeOEN) is an O-methylated metabolite in equine estrogen metabolism. O-methylation of catechol estrogens is considered as a protective mechanism; however, comparison of the proper... |
|
|
Mechanism of translesion synthesis past an equine estrogen-DNA adduct by Y-family DNA polymerases.
J. Mol. Biol. 371(5) , 1151-62, (2007) 4-Hydroxyequilenin (4-OHEN)-dC is a major, potentially mutagenic DNA adduct induced by equine estrogens used for hormone replacement therapy. To study the miscoding property of 4-OHEN-dC and the invol... |
| Equilenin solution |
| EQU |
| Equilenina |
| d-Equilenin |