6-Morpholinopyridin-3-amine

Modify Date: 2024-01-18 17:34:55

6-Morpholinopyridin-3-amine Structure
6-Morpholinopyridin-3-amine structure
Common Name 6-Morpholinopyridin-3-amine
CAS Number 52023-68-4 Molecular Weight 179.219
Density 1.2±0.1 g/cm3 Boiling Point 414.4±45.0 °C at 760 mmHg
Molecular Formula C9H13N3O Melting Point 126-128°C
MSDS USA Flash Point 204.4±28.7 °C

 Names

Name 6-Morpholinopyridin-3-amine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 414.4±45.0 °C at 760 mmHg
Melting Point 126-128°C
Molecular Formula C9H13N3O
Molecular Weight 179.219
Flash Point 204.4±28.7 °C
Exact Mass 179.105865
PSA 51.38000
LogP -0.30
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.595

 MSDS

Name: 6-Morpholinopyridin-3-amine 97% Material Safety Data Sheet
Synonym:
CAS: 52023-68-4
Section 1 - Chemical Product MSDS Name:6-Morpholinopyridin-3-amine 97% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
52023-68-4 6-Morpholinopyridin-3-amine 97% 257-613-3
Hazard Symbols: XN
Risk Phrases: 20/21/22

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 52023-68-4: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: pink
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 126 - 128 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H13N3O
Molecular Weight: 179

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, acid chlorides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 52023-68-4 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
6-Morpholinopyridin-3-amine - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group: III
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 52023-68-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 52023-68-4 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 52023-68-4 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S22-S36/37/39-S36/37
RIDADR 2811
HS Code 2934999090

 Synthetic Route

~99%

6-Morpholinopyridin-3-amine Structure

6-Morpholinopyr...

CAS#:52023-68-4

Literature: GLAXOSMITHKLINE LLC; ADJABENG, George; BAUM, Erich; BIFULCO, Neil; DAVIS-WARD, Ronda, G.; DICKERSON, Scott, Howard; DONALDSON, Kelly, Horne; HORNBERGER, Keith; PETROV, Kimberly; RHEAULT, Tara, Renae; SAMMOND, Douglas, McCord; SCHAAF, Gregory, M.; STELLWAGEN, John; UEHLING, David, Edward; WATERSON, Alex, Gregory Patent: WO2010/104899 A1, 2010 ; Location in patent: Page/Page column 106 ; WO 2010/104899 A1

~%

6-Morpholinopyridin-3-amine Structure

6-Morpholinopyr...

CAS#:52023-68-4

Literature: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis Patent: WO2013/126608 A1, 2013 ;

~%

6-Morpholinopyridin-3-amine Structure

6-Morpholinopyr...

CAS#:52023-68-4

Literature: Spencer, John; Patel, Hiren; Callear, Samantha K.; Coles, Simon J.; Deadman, John J. Tetrahedron Letters, 2011 , vol. 52, # 45 p. 5905 - 5909

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

6-(morpholin-4-yl)pyridin-3-amine
EINECS 257-613-3
6-morpholin-4-ylpyridin-3-amine
5-Amino-2-(4-morpholinyl)pyridine
MFCD00119562
6-(4-Morpholinyl)-3-pyridinamine
3-Pyridinamine, 6-(4-morpholinyl)-
4-(5-Amino-2-pyridyl)morpholine
6-Morpholinopyridin-3-Amine
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