Pyridoxamine dihydrochloride

Modify Date: 2024-01-02 21:46:22

Pyridoxamine dihydrochloride Structure
Pyridoxamine dihydrochloride structure
 Common Name Pyridoxamine dihydrochloride
CAS Number 524-36-7 Molecular Weight 241.115
Density 1.282g/cm3 Boiling Point 460.1ºC at 760 mmHg
Molecular Formula C8H14Cl2N2O2 Melting Point 224-226 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 232.1ºC

 Names

Name Pyridoxamine dihydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.282g/cm3
Boiling Point 460.1ºC at 760 mmHg
Melting Point 224-226 °C (dec.)(lit.)
Molecular Formula C8H14Cl2N2O2
Molecular Weight 241.115
Flash Point 232.1ºC
Exact Mass 240.043228
PSA 79.37000
LogP 2.35090
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV1230000
CHEMICAL NAME :
Pyridoxamine dihydrochloride
CAS REGISTRY NUMBER :
524-36-7
LAST UPDATED :
199504
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C8-H12-N2-O2.2Cl-H
MOLECULAR WEIGHT :
241.14
WISWESSER LINE NOTATION :
T6NJ B1 CQ D1Z E1Q &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4720 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2950 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
590 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
540 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
795 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4950 No. of Facilities: 6 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 44 (estimated) No. of Female Employees: 32 (estimated)

 Safety Information

Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS UV1230000
HS Code 2933399090

 Synthetic Route

2-methyl-3-hydroxy-4-cyano-5-acetyloxymethyl-pyridine structure

2-methyl-3-hydr...

CAS#:408335-89-7

~83%

Pyridoxamine dihydrochloride Structure

Pyridoxamine di...

CAS#:524-36-7

Literature: KANDULA, Mahesh Patent: WO2013/167991 A1, 2013 ; Location in patent: Paragraph 00103; 00104 ;
(5-acetoxy-4-((1,3-dioxoisoindolin-2-yl)methyl)-6-methylpyridin-3-yl)methyl acetate structure

(5-acetoxy-4-((...

CAS#:863030-57-3

~%

Pyridoxamine dihydrochloride Structure

Pyridoxamine di...

CAS#:524-36-7

Literature: BIOSTRATUM, INC. Patent: WO2005/77902 A2, 2005 ; Location in patent: Page/Page column 40-42 ;
2-Methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine oxime structure

2-Methyl-3-hydr...

CAS#:20905-66-2

~94%

Pyridoxamine dihydrochloride Structure

Pyridoxamine di...

CAS#:524-36-7

Literature: Balyakina, M. V.; Yakovleva, N. L.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 6 p. 407 - 409 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 6 p. 79 - 81
Pyridoxine hydrochloride structure

Pyridoxine hydr...

CAS#:58-56-0

~%

Pyridoxamine dihydrochloride Structure

Pyridoxamine di...

CAS#:524-36-7

Literature: Balyakina, M. V.; Yakovleva, N. L.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 6 p. 407 - 409 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 6 p. 79 - 81

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, dihydrochloride (9CI)
Pyridoxamine Dihydrochloride
Pyridoxamine Dihydrochloride Monohydrate
PYRIDOXAMINE HCL
PYRIDOXAMINE 2HCL
Pyridoxamine, dihydrochloride
4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride
EINECS 208-357-6
pyridoxamine bishydrochloride
pyridoxal amine dihydrochloride
pyridoxylamine dihydrochloride
pyridoxaminedihydrochloride
4-(Aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride
Dyridoxamine hydrochloride
vitamin B6dihydrochloride
Pyridoxamine DiHCl
Pyridoxamine dihydro
MFCD00012808
3-Pyridinemethanol, 4- (aminomethyl)-5-hydroxy-6-methyl-, dihydrochloride
PyridoxaMine 2HC1
3-Pyridinemethanol, 4-(aminomethyl)-5-hydroxy-6-methyl-, hydrochloride (1:2)
4-(Aminomethyl)-5-(hydroxymethyl)-2-methyl-3-pyridinol dihydrochloride
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